Pemphigus Foliaceus-Repeated Treatment With Rituximab 7 Years After Initial Response: A Case Report

被引：5

作者：

Kraft, Magdalena ^{[1
]}

Worm, Margitta ^{[1
]}

机构：

[1] Charite Univ Med Berlin, Allergy Ctr Charite, Dept Dermatol Venerol & Allergol, Berlin, Germany

来源：

FRONTIERS IN MEDICINE | 2018年 / 5卷

关键词：

pemphigus foliaceus; rituximab; anti-CD20; b-cell depletion; autoimmune blistering diseases; TERM-FOLLOW-UP; DOSE RITUXIMAB; SINGLE-CENTER; VULGARIS; THERAPY; PROTOCOL;

D O I：

10.3389/fmed.2018.00315

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Pemphigus foliaceus is an autoimmune skin disease mediated by autoantibodies directed against desmoglein-1 located in the upper epidermal layer. Rituximab, a monoclonal anit-CD20 antibody depleting b-cells, offers an effective treatment possibility for therapy-resistant pemphigus foliaceus. Here, we present the case of 55-year-old man who did not respond sufficiently to conventional treatment with prednisolone, azathioprine, and cyclophosphamide, but underwent almost complete remission after rituximab treatment. The patient relapsed 7 years later, and a repeated course of rituximab infusions led to a partial remission.

引用

页数：4

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