共 98 条
BET inhibitors: a novel epigenetic approach
被引:283
作者:

Doroshow, D. B.
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Dept Med, Sect Med Oncol, 333 Cedar St,WWW211,POB 208028, New Haven, CT 06520 USA

Eder, J. P.
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Dept Med, Sect Med Oncol, 333 Cedar St,WWW211,POB 208028, New Haven, CT 06520 USA

LoRusso, P. M.
论文数: 0 引用数: 0
h-index: 0
机构:
Yale Univ, Dept Med, Sect Med Oncol, 333 Cedar St,WWW211,POB 208028, New Haven, CT 06520 USA
Yale Canc Ctr, 333 Cedar St,WWW211,POB 208028, New Haven, CT 06520 USA Yale Univ, Dept Med, Sect Med Oncol, 333 Cedar St,WWW211,POB 208028, New Haven, CT 06520 USA
机构:
[1] Yale Univ, Dept Med, Sect Med Oncol, 333 Cedar St,WWW211,POB 208028, New Haven, CT 06520 USA
[2] Yale Canc Ctr, 333 Cedar St,WWW211,POB 208028, New Haven, CT 06520 USA
关键词:
BET inhibitors;
BET proteins;
epigenetic anticancer therapy;
BROMODOMAIN PROTEIN BRD4;
DOSE-ESCALATION;
THERAPEUTIC TARGET;
HDAC INHIBITORS;
ACUTE-LEUKEMIA;
OPEN-LABEL;
P-TEFB;
CANCER;
MYC;
TRANSCRIPTION;
D O I:
10.1093/annonc/mdx157
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
Epigenetics has been defined as 'the structural adaptation of chromosomal regions so as to register, signal or perpetuate altered activity states.' Currently, several classes of anticancer drugs function at the epigenetic level, including inhibitors of DNA methyltransferase, histone deacetylase (HDAC), lysine-specific demethylase 1, zeste homolog 2, and bromodomain and extraterminal motif (BET) proteins. BET proteins have multiple functions, including the initiation and elongation of transcription and cell cycle regulation. In recent years, inhibitors of BET proteins have been developed as anticancer agents. These inhibitors exhibit selectivity for tumor cells by preferentially binding to superenhancers, noncoding regions of DNA critical for the transcription of genes that determine a cell's identity. Preclinical research on BET inhibitors has identified them as a potential means of targeting MYC. Early clinical trials with BET inhibitors have had mixed results, with few responses in both hematologic and solid tumors that tend to be short-lived. Toxicities have included severe, thrombocytopenia, fatigue, nausea, vomiting, and diarrhea; GI side-effects, fatigue, and low-grade dysgeusia have limited compliance. However, preclinical data suggest that BET inhibitors may have a promising future in combination with other agents. They appear to be able to overcome resistance to targeted agents and have strong synergy with immune checkpoint inhibitors as well as with multiple epigenetic agents, particularly HDAC inhibitors. In many instances, BET and HDAC inhibitors were synergistic at reduced doses, suggesting a potential means of avoiding the overlapping toxicities of the two drug classes. BET inhibitors provide a novel approach to epigenetic anticancer therapy. However, to date they appear to have limited efficacy as single agents. A focus on BET inhibitors in combination with other drugs such as targeted and/or as other epigenetic agents is warranted, due to limited monotherapy activity, including pharmacodynamic correlatives differential activity amongst select drug combinations.
引用
收藏
页码:1776 / 1787
页数:12
相关论文
共 98 条
[51]
Mechanisms of tumor cell resistance to the current targeted-therapy agents
[J].
Khamisipour, Gholamreza
;
Jadidi-Niaragh, Farhad
;
Jahromi, Abdolreza Sotoodeh
;
Zandi, Keivan
;
Hojjat-Farsangi, Mohammad
.
TUMOR BIOLOGY,
2016, 37 (08)
:10021-10039

Khamisipour, Gholamreza
论文数: 0 引用数: 0
h-index: 0
机构:
Bushehr Univ Med Sci, Fac Allied Med, Dept Hematol, Bushehr, Iran Bushehr Univ Med Sci, Fac Allied Med, Dept Hematol, Bushehr, Iran

Jadidi-Niaragh, Farhad
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Tehran Med Sci, Sch Publ Hlth, Dept Immunol, Tehran, Iran
Tabriz Univ Med Sci, Immunol Res Ctr, Tabriz, Iran
Tabriz Univ Med Sci, Dept Immunol, Fac Med, Tabriz, Iran Bushehr Univ Med Sci, Fac Allied Med, Dept Hematol, Bushehr, Iran

Jahromi, Abdolreza Sotoodeh
论文数: 0 引用数: 0
h-index: 0
机构:
Jahrom Univ Med Sci, Res Ctr Noncommunicable Dis, Jahrom, Iran Bushehr Univ Med Sci, Fac Allied Med, Dept Hematol, Bushehr, Iran

Zandi, Keivan
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Malaya, Dept Med Microbiol, Trop Infect Dis Res & Educ Ctr, Fac Med, Kuala Lumpur, Malaysia Bushehr Univ Med Sci, Fac Allied Med, Dept Hematol, Bushehr, Iran

Hojjat-Farsangi, Mohammad
论文数: 0 引用数: 0
h-index: 0
机构:
Karolinska Univ Hosp Solna, Canc Ctr Karolinska CCK, Immune & Gene therapy Lab, Dept Oncol Pathol, SE-17176 Stockholm, Sweden
Karolinska Inst, SE-17176 Stockholm, Sweden
Bushehr Univ Med Sci, Sch Med, Dept Immunol, Bushehr, Iran Bushehr Univ Med Sci, Fac Allied Med, Dept Hematol, Bushehr, Iran
[52]
The BET inhibitor INCB054329 enhances the activity of checkpoint modulation in syngeneic tumor models
[J].
Koblish, Holly K.
;
Hansbury, Michael
;
Hall, Leslie
;
Wang, Liang-Chuan
;
Zhang, Yue
;
Covington, Maryanne
;
Burn, Timothy
;
Rupar, Mark
;
Gardiner, Christine
;
Condamine, Thomas
;
Lasky, Kerni
;
Stubbs, Matthew C.
;
Yue, Eddy
;
Sparks, Richard
;
Sparks, Richard
;
Maduskuie, Thomas
;
Combs, Andrew P.
;
Hollis, Gregory
;
Huber, Reid
;
Liu, Phillip C. C.
;
Scherle, Peggy
.
CANCER RESEARCH,
2016, 76

Koblish, Holly K.
论文数: 0 引用数: 0
h-index: 0

Hansbury, Michael
论文数: 0 引用数: 0
h-index: 0

Hall, Leslie
论文数: 0 引用数: 0
h-index: 0

Wang, Liang-Chuan
论文数: 0 引用数: 0
h-index: 0

Zhang, Yue
论文数: 0 引用数: 0
h-index: 0

Covington, Maryanne
论文数: 0 引用数: 0
h-index: 0

Burn, Timothy
论文数: 0 引用数: 0
h-index: 0

Rupar, Mark
论文数: 0 引用数: 0
h-index: 0

Gardiner, Christine
论文数: 0 引用数: 0
h-index: 0

Condamine, Thomas
论文数: 0 引用数: 0
h-index: 0

Lasky, Kerni
论文数: 0 引用数: 0
h-index: 0

Stubbs, Matthew C.
论文数: 0 引用数: 0
h-index: 0

Yue, Eddy
论文数: 0 引用数: 0
h-index: 0

Sparks, Richard
论文数: 0 引用数: 0
h-index: 0

Sparks, Richard
论文数: 0 引用数: 0
h-index: 0

Maduskuie, Thomas
论文数: 0 引用数: 0
h-index: 0

Combs, Andrew P.
论文数: 0 引用数: 0
h-index: 0

Hollis, Gregory
论文数: 0 引用数: 0
h-index: 0

Huber, Reid
论文数: 0 引用数: 0
h-index: 0

Liu, Phillip C. C.
论文数: 0 引用数: 0
h-index: 0

Scherle, Peggy
论文数: 0 引用数: 0
h-index: 0
[53]
Chromatin modifications and their function
[J].
Kouzarides, Tony
.
CELL,
2007, 128 (04)
:693-705

Kouzarides, Tony
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cambridge, Gurdon Inst, Cambridge CB2 1QN, England
[54]
Utilizing targeted cancer therapeutic agents in combination: novel approaches and urgent requirements
[J].
Kummar, Shivanni
;
Chen, Helen X.
;
Wright, John
;
Holbeck, Susan
;
Millin, Myrtle Davis
;
Tomaszewski, Joseph
;
Zweibel, James
;
Collins, Jerry
;
Doroshow, James H.
.
NATURE REVIEWS DRUG DISCOVERY,
2010, 9 (11)
:843-856

Kummar, Shivanni
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, Ctr Canc Res, NIH, Bethesda, MD 20892 USA NCI, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

Chen, Helen X.
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, Div Canc Treatment & Diag, NIH, Bethesda, MD 20892 USA NCI, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

Wright, John
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, Div Canc Treatment & Diag, NIH, Bethesda, MD 20892 USA NCI, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

Holbeck, Susan
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, Div Canc Treatment & Diag, NIH, Bethesda, MD 20892 USA NCI, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

Millin, Myrtle Davis
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, Div Canc Treatment & Diag, NIH, Bethesda, MD 20892 USA NCI, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

Tomaszewski, Joseph
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, Div Canc Treatment & Diag, NIH, Bethesda, MD 20892 USA NCI, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

Zweibel, James
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, Div Canc Treatment & Diag, NIH, Bethesda, MD 20892 USA NCI, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

Collins, Jerry
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, Div Canc Treatment & Diag, NIH, Bethesda, MD 20892 USA NCI, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

Doroshow, James H.
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, Ctr Canc Res, NIH, Bethesda, MD 20892 USA
NCI, Div Canc Treatment & Diag, NIH, Bethesda, MD 20892 USA NCI, Ctr Canc Res, NIH, Bethesda, MD 20892 USA
[55]
Synergistic effect of JQ1 and rapamycin for treatment of human osteosarcoma
[J].
Lee, Dhong Hyun
;
Qi, Jun
;
Bradner, James E.
;
Said, Jonathan W.
;
Doan, Ngan B.
;
Forscher, Charles
;
Yang, Henry
;
Koeffler, H. Phillip
.
INTERNATIONAL JOURNAL OF CANCER,
2015, 136 (09)
:2055-2064

Lee, Dhong Hyun
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Cedars Sinai Med Ctr, Sch Med, Div Hematol & Oncol, Los Angeles, CA 90048 USA Univ Calif Los Angeles, Cedars Sinai Med Ctr, Sch Med, Div Hematol & Oncol, Los Angeles, CA 90048 USA

Qi, Jun
论文数: 0 引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Div Hematol Neoplasia, Boston, MA 02115 USA Univ Calif Los Angeles, Cedars Sinai Med Ctr, Sch Med, Div Hematol & Oncol, Los Angeles, CA 90048 USA

Bradner, James E.
论文数: 0 引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Div Hematol Neoplasia, Boston, MA 02115 USA Univ Calif Los Angeles, Cedars Sinai Med Ctr, Sch Med, Div Hematol & Oncol, Los Angeles, CA 90048 USA

Said, Jonathan W.
论文数: 0 引用数: 0
h-index: 0
机构:
Santa Monica Univ Calif Los Angeles, Med Ctr, Dept Pathol & Lab Med, Los Angeles, CA USA Univ Calif Los Angeles, Cedars Sinai Med Ctr, Sch Med, Div Hematol & Oncol, Los Angeles, CA 90048 USA

Doan, Ngan B.
论文数: 0 引用数: 0
h-index: 0
机构:
Santa Monica Univ Calif Los Angeles, Med Ctr, Dept Pathol & Lab Med, Los Angeles, CA USA Univ Calif Los Angeles, Cedars Sinai Med Ctr, Sch Med, Div Hematol & Oncol, Los Angeles, CA 90048 USA

Forscher, Charles
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Cedars Sinai Med Ctr, Sch Med, Div Hematol & Oncol, Los Angeles, CA 90048 USA Univ Calif Los Angeles, Cedars Sinai Med Ctr, Sch Med, Div Hematol & Oncol, Los Angeles, CA 90048 USA

Yang, Henry
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Univ Singapore, Natl Canc Inst, Singapore 117548, Singapore
Natl Univ Singapore, Canc Sci Inst, Singapore 117548, Singapore Univ Calif Los Angeles, Cedars Sinai Med Ctr, Sch Med, Div Hematol & Oncol, Los Angeles, CA 90048 USA

Koeffler, H. Phillip
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Cedars Sinai Med Ctr, Sch Med, Div Hematol & Oncol, Los Angeles, CA 90048 USA
Natl Univ Singapore, Natl Canc Inst, Singapore 117548, Singapore
Natl Univ Singapore, Canc Sci Inst, Singapore 117548, Singapore Univ Calif Los Angeles, Cedars Sinai Med Ctr, Sch Med, Div Hematol & Oncol, Los Angeles, CA 90048 USA
[56]
The double bromodomain proteins Brd2 and Brd3 couple histone acetylation to transcription
[J].
LeRoy, Gary
;
Rickards, Brenden
;
Flint, S. J.
.
MOLECULAR CELL,
2008, 30 (01)
:51-60

LeRoy, Gary
论文数: 0 引用数: 0
h-index: 0
机构:
Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA

Rickards, Brenden
论文数: 0 引用数: 0
h-index: 0
机构:
Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA

Flint, S. J.
论文数: 0 引用数: 0
h-index: 0
机构:
Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA
[57]
Macro/Microtesting and Damage and Degradation of Sandstones under Dry-Wet Cycles
[J].
Liu, Xinrong
;
Wang, Zijuan
;
Fu, Yan
;
Yuan, Wen
;
Miao, Luli
.
ADVANCES IN MATERIALS SCIENCE AND ENGINEERING,
2016, 2016

Liu, Xinrong
论文数: 0 引用数: 0
h-index: 0
机构:
Chongqing Univ, Coll Civil Engn, Chongqing 400045, Peoples R China
Chongqing Univ, Minist Educ, Key Lab New Technol Construct Cities Mt Area, Chongqing 400045, Peoples R China Chongqing Univ, Coll Civil Engn, Chongqing 400045, Peoples R China

Wang, Zijuan
论文数: 0 引用数: 0
h-index: 0
机构:
Chongqing Univ, Coll Civil Engn, Chongqing 400045, Peoples R China
Chongqing Univ, Minist Educ, Key Lab New Technol Construct Cities Mt Area, Chongqing 400045, Peoples R China Chongqing Univ, Coll Civil Engn, Chongqing 400045, Peoples R China

Fu, Yan
论文数: 0 引用数: 0
h-index: 0
机构:
Chongqing Univ, Coll Construct Management & Real Estate, Chongqing 400045, Peoples R China Chongqing Univ, Coll Civil Engn, Chongqing 400045, Peoples R China

Yuan, Wen
论文数: 0 引用数: 0
h-index: 0
机构:
Chongqing Univ, Coll Civil Engn, Chongqing 400045, Peoples R China
Chongqing Univ, Minist Educ, Key Lab New Technol Construct Cities Mt Area, Chongqing 400045, Peoples R China Chongqing Univ, Coll Civil Engn, Chongqing 400045, Peoples R China

Miao, Luli
论文数: 0 引用数: 0
h-index: 0
机构:
Chongqing Univ, Coll Civil Engn, Chongqing 400045, Peoples R China
Chongqing Univ, Minist Educ, Key Lab New Technol Construct Cities Mt Area, Chongqing 400045, Peoples R China Chongqing Univ, Coll Civil Engn, Chongqing 400045, Peoples R China
[58]
Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers
[J].
Loven, Jakob
;
Hoke, Heather A.
;
Lin, Charles Y.
;
Lau, Ashley
;
Orlando, David A.
;
Vakoc, Christopher R.
;
Bradner, James E.
;
Lee, Tong Ihn
;
Young, Richard A.
.
CELL,
2013, 153 (02)
:320-334

Loven, Jakob
论文数: 0 引用数: 0
h-index: 0
机构:
Whitehead Inst Biomed Res, Cambridge, MA 02142 USA Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

Hoke, Heather A.
论文数: 0 引用数: 0
h-index: 0
机构:
Whitehead Inst Biomed Res, Cambridge, MA 02142 USA
MIT, Dept Biol, Cambridge, MA 02139 USA Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

Lin, Charles Y.
论文数: 0 引用数: 0
h-index: 0
机构:
Whitehead Inst Biomed Res, Cambridge, MA 02142 USA
MIT, Computat & Syst Biol Program, Cambridge, MA 02139 USA
Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

Lau, Ashley
论文数: 0 引用数: 0
h-index: 0
机构:
Whitehead Inst Biomed Res, Cambridge, MA 02142 USA
MIT, Dept Biol, Cambridge, MA 02139 USA Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

Orlando, David A.
论文数: 0 引用数: 0
h-index: 0
机构:
Whitehead Inst Biomed Res, Cambridge, MA 02142 USA Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

Vakoc, Christopher R.
论文数: 0 引用数: 0
h-index: 0
机构:
Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

Bradner, James E.
论文数: 0 引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

Lee, Tong Ihn
论文数: 0 引用数: 0
h-index: 0
机构:
Whitehead Inst Biomed Res, Cambridge, MA 02142 USA Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

Young, Richard A.
论文数: 0 引用数: 0
h-index: 0
机构:
Whitehead Inst Biomed Res, Cambridge, MA 02142 USA
MIT, Dept Biol, Cambridge, MA 02139 USA Whitehead Inst Biomed Res, Cambridge, MA 02142 USA
[59]
A phase lb trial with MK-8628/OTX015, a small molecule inhibitor of bromodomain (BRD) and extra-terminal (BET) proteins, in patients with selected advanced solid tumors
[J].
Massard, C.
;
Soria, J. C.
;
Stathis, A.
;
Delord, J. P.
;
Awada, A.
;
Peters, S.
;
Lewin, J.
;
Bekradda, M.
;
Rezai, K.
;
Zeng, Z.
;
Azher, H.
;
Perez, S.
;
Siu, L.
.
EUROPEAN JOURNAL OF CANCER,
2016, 69
:S2-S3

Massard, C.
论文数: 0 引用数: 0
h-index: 0
机构:
Gustave Roussy, Dept Med Oncol, Le Kremlin Bicetre, France Gustave Roussy, Dept Med Oncol, Le Kremlin Bicetre, France

Soria, J. C.
论文数: 0 引用数: 0
h-index: 0
机构:
Gustave Roussy, Dept Med Oncol, Le Kremlin Bicetre, France Gustave Roussy, Dept Med Oncol, Le Kremlin Bicetre, France

Stathis, A.
论文数: 0 引用数: 0
h-index: 0
机构:
Oncol Inst Southern Switzerland, Lymphoma Unit, Bellinzona, Switzerland Gustave Roussy, Dept Med Oncol, Le Kremlin Bicetre, France

Delord, J. P.
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Claudius Regaud, Dept Med Oncol, Toulouse, France Gustave Roussy, Dept Med Oncol, Le Kremlin Bicetre, France

Awada, A.
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Jules Bordet, Dept Med Oncol, Brussels, Belgium Gustave Roussy, Dept Med Oncol, Le Kremlin Bicetre, France

Peters, S.
论文数: 0 引用数: 0
h-index: 0
机构:
CHU Vaudois, Lausanne, Switzerland
Univ Lausanne Hosp, Dept Med Oncol, Lausanne, Switzerland Gustave Roussy, Dept Med Oncol, Le Kremlin Bicetre, France

Lewin, J.
论文数: 0 引用数: 0
h-index: 0
机构:
Princess Margaret Canc Ctr, Clin Canc Res Unit, Toronto, ON, Canada Gustave Roussy, Dept Med Oncol, Le Kremlin Bicetre, France

Bekradda, M.
论文数: 0 引用数: 0
h-index: 0
机构:
OTD, Med Oncol, Clichy, France Gustave Roussy, Dept Med Oncol, Le Kremlin Bicetre, France

Rezai, K.
论文数: 0 引用数: 0
h-index: 0
机构:
Hop Rene Huguenin, Inst Curie, Dept Med Oncol, St Cloud, France Gustave Roussy, Dept Med Oncol, Le Kremlin Bicetre, France

Zeng, Z.
论文数: 0 引用数: 0
h-index: 0
机构:
MRL, Dept Stat, 126 East Lincoln Ave, Rahway, NJ USA Gustave Roussy, Dept Med Oncol, Le Kremlin Bicetre, France

Azher, H.
论文数: 0 引用数: 0
h-index: 0
机构:
MRL, Dept Pharmacokinet, 126 East Lincoln Ave, Rahway, NJ USA Gustave Roussy, Dept Med Oncol, Le Kremlin Bicetre, France

Perez, S.
论文数: 0 引用数: 0
h-index: 0
机构:
MRL, Dept Oncol, 126 East Lincoln Ave, Rahway, NJ USA Gustave Roussy, Dept Med Oncol, Le Kremlin Bicetre, France

Siu, L.
论文数: 0 引用数: 0
h-index: 0
机构:
Princess Margaret Canc Ctr, Clin Canc Res Unit, Toronto, ON, Canada Gustave Roussy, Dept Med Oncol, Le Kremlin Bicetre, France
[60]
Targeting MYC dependence in cancer by inhibiting BET bromodomains
[J].
Mertz, Jennifer A.
;
Conery, Andrew R.
;
Bryant, Barbara M.
;
Sandy, Peter
;
Balasubramanian, Srividya
;
Mele, Deanna A.
;
Bergeron, Louise
;
Sims, Robert J., III
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
2011, 108 (40)
:16669-16674

Mertz, Jennifer A.
论文数: 0 引用数: 0
h-index: 0
机构:
Constellat Pharmaceut Inc, Cambridge, MA 02142 USA Constellat Pharmaceut Inc, Cambridge, MA 02142 USA

Conery, Andrew R.
论文数: 0 引用数: 0
h-index: 0
机构:
Constellat Pharmaceut Inc, Cambridge, MA 02142 USA Constellat Pharmaceut Inc, Cambridge, MA 02142 USA

Bryant, Barbara M.
论文数: 0 引用数: 0
h-index: 0
机构:
Constellat Pharmaceut Inc, Cambridge, MA 02142 USA Constellat Pharmaceut Inc, Cambridge, MA 02142 USA

Sandy, Peter
论文数: 0 引用数: 0
h-index: 0
机构:
Constellat Pharmaceut Inc, Cambridge, MA 02142 USA Constellat Pharmaceut Inc, Cambridge, MA 02142 USA

Balasubramanian, Srividya
论文数: 0 引用数: 0
h-index: 0
机构:
Constellat Pharmaceut Inc, Cambridge, MA 02142 USA Constellat Pharmaceut Inc, Cambridge, MA 02142 USA

Mele, Deanna A.
论文数: 0 引用数: 0
h-index: 0
机构:
Constellat Pharmaceut Inc, Cambridge, MA 02142 USA Constellat Pharmaceut Inc, Cambridge, MA 02142 USA

Bergeron, Louise
论文数: 0 引用数: 0
h-index: 0
机构:
Constellat Pharmaceut Inc, Cambridge, MA 02142 USA Constellat Pharmaceut Inc, Cambridge, MA 02142 USA

Sims, Robert J., III
论文数: 0 引用数: 0
h-index: 0
机构:
Constellat Pharmaceut Inc, Cambridge, MA 02142 USA Constellat Pharmaceut Inc, Cambridge, MA 02142 USA