A Diastereoselective Synthesis of Phosphorylated Dihydro-1H-pyrazoles from Dialkyl Phosphites, Acetylenic Esters, and Hydrazonoyl Chlorides

被引：12

作者：

Yavari, Issa ^{[1
]}

Khalili, Gholamhossein ^{[1
]}

机构：

[1] Tarbiat Modares Univ, Dept Chem, Tehran, Iran

来源：

SYNLETT | 2010年 / 12期

关键词：

pyrazoles; trialkyl phosphites; acetylenic esters; hydrazonoyl chlorides; MCR; PHASE SYNTHESIS; PYRAZOLE;

D O I：

10.1055/s-0030-1258118

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The 1:1 zwitterionic intermediates formed from the reaction of trialkyl phosphites with acetylenic esters were trapped by hydrazonoyl chlorides to yield dialkyl 4-(dialkoxyphosphoryl)-1-phenyl-3-aryl-4,5-dihydro-1H-pyrazole-4,5-dicarboxylates in good yields. This three-component synthesis of phosphorylated dihydro-1H-pyrazoles produces only one diasteromer.

引用

页码：1862 / 1864

页数：3

共 20 条

[1] A novel one-pot method for the preparation of pyrazoles by 1,3-dipolar cycloadditions of diazo compounds generated in situ [J].