Progress toward molecular therapy for diabetes mellitus: A focus on targeting inflammatory factors

被引：27

作者：

Dehghan, Mohadesse ^{[1
]}

Ghorbani, Fateme ^{[2
]}

Najafi, Sajad ^{[3
]}

Ravaei, Neda ^{[4
]}

Karimian, Maede ^{[5
]}

Kalhor, Kambiz ^{[6
]}

Movafagh, Abolfazl ^{[7
]}

Zarch, Seyed Mohsen Aghaei ^{[7
]}

机构：

[1] Islamic Azad Univ, Dept Microbiol, North Tehran Branch, Facul Life Sci, Tehran, Iran

[2] Islamic Azad Univ, Dept Biol, Tonekabon Branch, Tehran, Mazandran, Iran

[3] Shahid Beheshti Univ Med Sci, Sch Adv Technol Med, Dept Med Biotechnol, Tehran, Iran

[4] Islamic Azad Univ, Fac Basic Sci, Dept Genet, Tehran, Iran

[5] Shahid Sadoughi Univ Med Sci, Sch Med, Dept Med Genet, Prot Engn Lab, Yazd, Iran

[6] Univ Tennessee, Dept Earth & Planetary Sci, Knoxville, TN USA

[7] Shahid Beheshti Univ Med Sci, Sch Med, Dept Med Genet, Tehran, Iran

来源：

DIABETES RESEARCH AND CLINICAL PRACTICE | 2022年 / 189卷

关键词：

Diabetes Mellitus; Molecular Therapy; Inflammatory factors; NF-KAPPA-B; INSULIN-RESISTANCE; SKELETAL-MUSCLE; EXPRESSION; TYPE-1; PATHWAYS; DELIVERY; MIR-146; ROLES; STAT3;

D O I：

10.1016/j.diabres.2022.109945

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Diabetes mellitus (DM) has been the most prevalent global metabolic disease, turning into a serious risk for human health. Several researches have recorded a role for inflammation and immunity in the pathogenesis of both in T1DM and in T2DM. Lots of chemical agents are available to control and to cure diabetic patients, which are not always sufficient for euglycemia maintenance and late stage diabetic complications avoidance. Therefore, newborn therapeutic methods to refine clinical outcomes in DM are required. Nucleic-acid-based therapy also known as gene expression level regulator within the target cells has been calculated to be promising in various diseases. Thus, pronounced attempts have been dedicated to develop new targeted molecular therapy aimed at improving insulin resistance in DM. This review mainly focuses on recent progress in DM molecular therapy and whether, has potential efficacy against inflammatory mediators involved in DM.

引用

页数：10

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