Progress toward molecular therapy for diabetes mellitus: A focus on targeting inflammatory factors

被引：27
作者：
Dehghan, Mohadesse [1 ]
Ghorbani, Fateme [2 ]
Najafi, Sajad [3 ]
Ravaei, Neda [4 ]
Karimian, Maede [5 ]
Kalhor, Kambiz [6 ]
Movafagh, Abolfazl [7 ]
Zarch, Seyed Mohsen Aghaei [7 ]
机构：
[1] Islamic Azad Univ, Dept Microbiol, North Tehran Branch, Facul Life Sci, Tehran, Iran
[2] Islamic Azad Univ, Dept Biol, Tonekabon Branch, Tehran, Mazandran, Iran
[3] Shahid Beheshti Univ Med Sci, Sch Adv Technol Med, Dept Med Biotechnol, Tehran, Iran
[4] Islamic Azad Univ, Fac Basic Sci, Dept Genet, Tehran, Iran
[5] Shahid Sadoughi Univ Med Sci, Sch Med, Dept Med Genet, Prot Engn Lab, Yazd, Iran
[6] Univ Tennessee, Dept Earth & Planetary Sci, Knoxville, TN USA
[7] Shahid Beheshti Univ Med Sci, Sch Med, Dept Med Genet, Tehran, Iran
来源：
DIABETES RESEARCH AND CLINICAL PRACTICE | 2022年 / 189卷
关键词：
Diabetes Mellitus; Molecular Therapy; Inflammatory factors; NF-KAPPA-B; INSULIN-RESISTANCE; SKELETAL-MUSCLE; EXPRESSION; TYPE-1; PATHWAYS; DELIVERY; MIR-146; ROLES; STAT3;
D O I：
10.1016/j.diabres.2022.109945
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Diabetes mellitus (DM) has been the most prevalent global metabolic disease, turning into a serious risk for human health. Several researches have recorded a role for inflammation and immunity in the pathogenesis of both in T1DM and in T2DM. Lots of chemical agents are available to control and to cure diabetic patients, which are not always sufficient for euglycemia maintenance and late stage diabetic complications avoidance. Therefore, newborn therapeutic methods to refine clinical outcomes in DM are required. Nucleic-acid-based therapy also known as gene expression level regulator within the target cells has been calculated to be promising in various diseases. Thus, pronounced attempts have been dedicated to develop new targeted molecular therapy aimed at improving insulin resistance in DM. This review mainly focuses on recent progress in DM molecular therapy and whether, has potential efficacy against inflammatory mediators involved in DM.
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页数：10
相关论文
共 84 条
[1]   The Role of Protein Tyrosine Phosphatase (PTP)-1B in Cardiovascular Disease and Its Interplay with Insulin Resistance [J].
Abdelsalam, Shahenda S. ;
Korashy, Hesham M. ;
Zeidan, Asad ;
Agouni, Abdelali .
BIOMOLECULES, 2019, 9 (07)
[2]   Adiponectin, a Therapeutic Target for Obesity, Diabetes, and Endothelial Dysfunction [J].
Achari, Arunkumar E. ;
Jain, Sushil K. .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 18 (06)
[3]  
Aghaei Zarch SM., 2019, J MAZANDARAN U MED S, V29, P195
[4]   Tumor Necrosis Factor-Alpha: Role in Development of Insulin Resistance and Pathogenesis of Type 2 Diabetes Mellitus [J].
Akash, Muhammad Sajid Hamid ;
Rehman, Kanwal ;
Liaqat, Aamira .
JOURNAL OF CELLULAR BIOCHEMISTRY, 2018, 119 (01) :105-110
[5]   Administration of resveratrol: What formulation solutions to bioavailability limitations? [J].
Amri, A. ;
Chaumeil, J. C. ;
Sfar, S. ;
Charrueau, C. .
JOURNAL OF CONTROLLED RELEASE, 2012, 158 (02) :182-193
[6]   Treatment of insulin resistance in obesity-associated type 2 diabetes mellitus through adiponectin gene therapy [J].
Banerjee, Amrita ;
Sharma, Divya ;
Trivedi, Riddhi ;
Singh, Jagdish .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2020, 583
[7]   Effects of vitamin D on insulin resistance and myosteatosis in diet-induced obese mice [J].
Benetti, Elisa ;
Mastrocola, Raffaella ;
Chiazza, Fausto ;
Nigro, Debora ;
D'Antona, Giuseppe ;
Bordano, Valentina ;
Fantozzi, Roberto ;
Aragno, Manuela ;
Collino, Massimo ;
Minetto, Marco Alessandro .
PLOS ONE, 2018, 13 (01)
[8]   Xuezhikang Therapy Increases miR-33 Expression in Patients with Low HDL-C Levels [J].
Cao, Ruihua ;
Bai, Yongyi ;
Sun, Lan ;
Zheng, Jin ;
Zu, Mian ;
Du, Guanhua ;
Ye, Ping .
DISEASE MARKERS, 2014, 2014
[9]   Exosomes and Their Noncoding RNA Cargo Are Emerging as New Modulators for Diabetes Mellitus [J].
Chang, Wenguang ;
Wang, Jianxun .
CELLS, 2019, 8 (08)
[10]   Vasoactive intestinal peptide dampens formyl-peptide-induced ROS production and inflammation by targeting a MAPK-p47phox phosphorylation pathway in monocytes [J].
Chedid, P. ;
Boussetta, T. ;
Dang, P. M-C ;
Belambri, S. A. ;
Marzaioli, V. ;
Fasseau, M. ;
Walker, F. ;
Couvineau, A. ;
El-Benna, J. ;
Marie, J-C .
MUCOSAL IMMUNOLOGY, 2017, 10 (02) :332-340
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