Plasma CD36 and Incident Diabetes: A Case-Cohort Study in Danish Men and Women

被引:3
作者
Wang, Yeli [1 ]
Zhu, Jingwen [2 ]
Aroner, Sarah [2 ]
Overvad, Kim [3 ,4 ]
Cai, Tianxi [5 ]
Yang, Ming [5 ]
Tjonneland, Anne [6 ]
Handberg, Aase [7 ,8 ]
Jensen, Majken K. [2 ,9 ]
机构
[1] Duke NUS Med Sch, Hlth Serv & Syst Res, Singapore, Singapore
[2] Harvard TH Chan Sch Publ Hlth, Dept Nutr, 677 Huntington Ave, Boston, MA 02115 USA
[3] Aalborg Univ Hosp, Dept Cardiol, Aalborg, Denmark
[4] Aarhus Univ, Dept Publ Hlth, Sect Epidemiol, Aarhus, Denmark
[5] Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA
[6] Danish Canc Soc Res Ctr, Copenhagen, Denmark
[7] Aalborg Univ Hosp, Dept Clin Biochem, Aalborg, Denmark
[8] Aalborg Univ, Fac Med, Dept Clin Med, Aalborg, Denmark
[9] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA
关键词
Adiposity; Biomarkers; CD36; antigens; Diabetes mellitus; type; 2; Epidemiology; Prospective studies; SCAVENGER RECEPTOR CD36; GENOME-WIDE LINKAGE; INSULIN-RESISTANCE; FATTY-ACID; METABOLIC SYNDROME; HUMAN OBESITY; SOLUBLE CD36; EXPRESSION; GLUCOSE; RISK;
D O I
10.4093/dmj.2018.0273
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Membrane CD36 is a fatty acid transporter implicated in the pathogenesis of metabolic disease. We aimed to evaluate the association between plasma CD36 levels and diabetes risk and to examine if the association was independent of adiposity among Danish population. Methods: We conducted a case-cohort study nested within the Danish Diet, Cancer and Health study among participants free of cardiovascular disease, diabetes and cancer and with blood samples and anthropometric measurements (height, weight, waist circumference, and body fat percentage) at baseline (1993 to 1997). CD36 levels were measured in 647 incident diabetes cases that occurred before December 2011 and a total of 3,515 case-cohort participants (236 cases overlap). Results: Higher plasma CD36 levels were associated with higher diabetes risk after adjusting for age, sex and other lifestyle factors. The hazard ratio (HR) comparing high versus low tertile of plasma CD36 levels was 1.36 (95% confidence interval [CI], 1.00 to 1.86). However, the association lost its significance after further adjustment for different adiposity indices such as body mass index (HR, 1.23; 95% CI, 0.87 to 1.73), waist circumference (HR, 1.21; 95% CI, 0.88 to 1.68) or body fat percentage (HR, 1.20; 95% CI, 0.86 to 1.66). Moreover, raised plasma CD36 levels were moderately associated with diabetes risk among lean participants, but the association was not present among overweight/obese individuals. Conclusion: Higher plasma CD36 levels were associated with higher diabetes risk, but the association was not independent of adiposity. In this Danish population, the association of CD36 with diabetes risk could be either mediated or confounded by adiposity.
引用
收藏
页码:134 / 142
页数:9
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