Long Term Outcome of Routine Image-enhanced Endoscopy in Newly Diagnosed Head and Neck Cancer: a Prospective Study of 145 Patients

被引：13

作者：

Chung, Chen-Shuan ^{[1
,2
]}

Lo, Wu-Chia ^{[3
]}

Wen, Ming-Hsun ^{[3
]}

Hsieh, Chen-Hsi ^{[4
,5
]}

Lin, Yu-Chin ^{[6
,7
]}

Liao, Li-Jen ^{[3
,8
]}

机构：

[1] Far Eastern Mem Hosp, Dept Internal Med, New Taipei, Taiwan

[2] Fu Jen Catholic Univ, Far Eastern Mem Hosp, Coll Med, New Taipei, Taiwan

[3] Far Eastern Mem Hosp, Dept Otolaryngol, New Taipei, Taiwan

[4] Far Eastern Mem Hosp, Dept Radiat Oncol, New Taipei, Taiwan

[5] Natl Yang Ming Univ, Sch Med, Far Eastern Mem Hosp, Dept Med, Taipei, Taiwan

[6] Far Eastern Mem Hosp, Dept Med Oncol, New Taipei, Taiwan

[7] Far Eastern Mem Hosp, Dept Hematol, New Taipei, Taiwan

[8] Yuan Ze Univ, Dept Elect Engn, Taoyuan, Taiwan

来源：

SCIENTIFIC REPORTS | 2016年 / 6卷

关键词：

SQUAMOUS-CELL CARCINOMA; 2ND PRIMARY TUMORS; ESOPHAGEAL CANCER; NEOPLASIA; SURVIVAL; ASSOCIATION; IMPACT;

D O I：

10.1038/srep29573

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Synchronous second primary tumors (SPTs), especially esophageal squamous cell neoplasia (ESCN), in patients with head and neck squamous cell carcinoma (HNSCC) are not uncommon. Image-enhanced endoscopy (IEE) screening may identify SPTs while there is no evidence to support its benefit. We prospectively recruited an adult cohort with newly-diagnosed HNSCC for IEE screening of upper gastrointestinal (UGI) tract neoplasia. 145 HNSCC patients were recruited. 22 (15.2%) patients had synchronous UGI tract neoplasia, including 20 ESCNs and 2 gastric adenocarcinoma. At a median follow-up of 2.72 (+/- 1.73) years, the 3-year overall survival (OS) rate was 0.71. HNSCC patients with synchronous ESCN/UGI tract neoplasia had poorer prognosis than those without (multivariate analysis, hazard ratio [HR] 2.75/2.79, 95% confidence interval [CI] 1.11 similar to 6.82/ 1.15 similar to 6.80, p = 0.03/0.02). HNSCC patients with advanced (stage III&IV) ESCN had worst survivals (p < 0.001). Among those with synchronous ESCNs, hypopharyngeal cancers were associated with poorer prognosis when compared with oral cancers (HR 2.36, 95% CI 1.08 similar to 5.15, p = 0.03). IEE screening for UGI SPTs in HNSCC patients could be used for risk stratification and prognosis prediction. HNSCC patients with advanced ESCN had the worst prognosis. Further studies are needed to demonstrate the survival benefits from IEE screening.

引用

页数：8

共 30 条

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