Reductive alkylation of aromatic amines with enol ethers

被引：13
作者：
Reddy, TJ [1 ]
Leclair, M [1 ]
Proulx, M [1 ]
机构：
[1] Virochem Pharma Inc, Laval, PQ H7V 4A7, Canada
来源：
SYNLETT | 2005年 / 04期
关键词：
reductive alkylation; aromatic amines; 2-methoxypropene; trimethylsilylenol ethers; sodium triacetoxyborohydride;
D O I：
10.1055/s-2005-863704
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Reductive alkylation of aromatic amines with 2-methoxypropene using 1.0 equivalent of HOAc and NaBH(OAc)(3) in 1,2-dichloroethane (DCE) at room temperature furnished N-isopropyl amines in 50-98% yields. This method was successfully extended to trimethylsilyl enol ethers. The mild reaction conditions provide a new alternative procedure for the reductive amination of electron deficient aromatic amines.
引用
收藏
页码：583 / 586
页数：4
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