Reductive alkylation of aromatic amines with enol ethers

被引：13

作者：

Reddy, TJ ^{[1
]}

Leclair, M ^{[1
]}

Proulx, M ^{[1
]}

机构：

[1] Virochem Pharma Inc, Laval, PQ H7V 4A7, Canada

来源：

SYNLETT | 2005年 / 04期

关键词：

reductive alkylation; aromatic amines; 2-methoxypropene; trimethylsilylenol ethers; sodium triacetoxyborohydride;

D O I：

10.1055/s-2005-863704

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reductive alkylation of aromatic amines with 2-methoxypropene using 1.0 equivalent of HOAc and NaBH(OAc)(3) in 1,2-dichloroethane (DCE) at room temperature furnished N-isopropyl amines in 50-98% yields. This method was successfully extended to trimethylsilyl enol ethers. The mild reaction conditions provide a new alternative procedure for the reductive amination of electron deficient aromatic amines.

引用

页码：583 / 586

页数：4

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