Colistin-Nonsusceptible Pseudomonas aeruginosa Sequence Type 654 with blaNDM-1 Arrives in North America

被引：43

作者：

Mataseje, L. F. ^{[1
]}

Peirano, G. ^{[2
]}

Church, D. L. ^{[2
,3
,4
,6
]}

Conly, J. ^{[2
,3
,4
,5
,6
]}

Mulvey, M. ^{[1
]}

Pitout, J. D. ^{[2
,3
,5
,6
,7
]}

机构：

[1] Natl Microbiol Lab, Winnipeg, MB, Canada

[2] Calgary Lab Serv, Div Microbiol, Calgary, AB, Canada

[3] Univ Calgary, Cumming Sch Med, Dept Pathol & Lab Med, Calgary, AB, Canada

[4] Univ Calgary, Cumming Sch Med, Dept Med, Calgary, AB, Canada

[5] Univ Calgary, Cumming Sch Med, Dept Microbiol Immunol & Infect Dis, Calgary, AB, Canada

[6] Univ Calgary, Cumming Sch Med, Snyder Inst Chron Dis, Calgary, AB, Canada

[7] Univ Pretoria, Dept Med Microbiol, ZA-0002 Pretoria, South Africa

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2016年 / 60卷 / 03期

关键词：

METALLO-BETA-LACTAMASE; KLEBSIELLA-PNEUMONIAE; MOLECULAR CHARACTERIZATION; GLOBAL SPREAD; CARBAPENEMASE; NDM-1; ENTEROBACTERIACEAE; PLASMIDS; IDENTIFICATION; DISSEMINATION;

D O I：

10.1128/AAC.02591-15

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

This study describes 3 different bla(NDM-1) genetic platforms in 3 different species obtained from the same patient who was directly transferred to an institution in Calgary, Alberta, Canada, following a prolonged hospital stay in India. The bla(NDM-1) in the Escherichia coli isolate was located on a 176-kb IncA/C plasmid contained within an ISCR1 region. The bla(NDM-1) in the Providencia rettgeri isolate was located on a 117-kb IncT plasmid contained within Tn3000, while the bla(NDM-1) in the Pseudomonas aeruginosa isolate was located on the chromosome within an ISCR3 region. This report highlights the plasticity of the genetic regions and environments associated with bla(NDM-1). To the best of our knowledge, this is the first report of P. aeruginosa with bla(NDM-1) identified in North America and the first report of bla(OXA-181) in P. rettgeri. The P. aeruginosa isolate belonged to the international high-risk sequence type 654 clone and was nonsusceptible to colistin. This case emphasizes the need for the use of appropriate infection prevention and control measures and vigilant screening for carbapenem-resistant Gram-negative bacteria in patients with a history of travel to areas of endemicity, such as the Indian subcontinent.

引用

页码：1794 / 1800

页数：7

共 44 条

[31] Molecular Epidemiology of Metallo-β-Lactamase-Producing Pseudomonas aeruginosa Isolates from Norway and Sweden Shows Import of International Clones and Local Clonal Expansion [J].