Nanomaterial and advanced technologies in transdermal drug delivery

被引:68
作者
Rabiei, Morteza [1 ]
Kashanian, Soheila [2 ,3 ,4 ]
Samavati, Seyedeh Sabereh [1 ]
Jamasb, Shahriar [5 ]
McInnes, Steven J. P. [6 ]
机构
[1] Razi Univ, Dept Nanobiotechnol, Kermanshah, Iran
[2] Razi Univ, Fac Chem, SBRC, POB 67149, Kermanshah, Iran
[3] Razi Univ, NNRC, POB 67149, Kermanshah, Iran
[4] Kermanshah Univ Med Sci, Nano Drug Delivery Res Ctr, Kermanshah, Iran
[5] Hamedan Univ Technol, Dept Biomed Engn, Hamadan, Hamadan, Iran
[6] Univ South Australia, Sch Engn, Div Informat Technol Engn & Environm, Adelaide, SA, Australia
关键词
Transdermal drug delivery; nanoparticle; skin patch; microneedle; stratum corneum; IN-VITRO CHARACTERIZATION; MICRONEEDLE ARRAYS; DISSOLVING MICRONEEDLES; PHOSPHOLIPID COMPLEX; SKIN PERMEATION; VIVO EVALUATION; NANO-VESICLES; EX-VIVO; FORMULATION; SYSTEM;
D O I
10.1080/1061186X.2019.1693579
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Transdermal drug delivery (TDD) is an alternative method of drug administration for drugs whose delivery by conventional oral, topical, intravenous and intramuscular methods is of limited efficacy. Recent advances in TDD involve the use of nanoparticles (NPs), which exhibit a great potential to enhance drug permeation across the skin. NPs can also provide controlled release, the ability to deliver both hydrophilic and hydrophobic drugs and reduce side effects, and when used in a TDD method they are also non-invasive. Another developing technology for TDD employs skin patches containing microneedles. Microneedles represent a painless and minimally invasive method of TDD in which micron-sized pores are created in the epidermis to allow delivery of drugs to the blood vessels present in the dermal layer of the skin. New researches have focussed on combining different TDD approaches to overcome previous constraints of drug delivery via conventional methods.
引用
收藏
页码:356 / 367
页数:12
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