Robust kinetic model for quantification of P-glycoprotein (P-gp) function under altered metabolism and after P-gp inhibition using (R)[C-11]verapamil and PET

被引:0
作者
Wang, Shaonan [1 ]
Feldmann, Maria [2 ]
Hinz, Rainer [1 ]
McMahon, Adam [1 ]
Koepp, Matthias [2 ]
Jackson, Alan [1 ]
Asselin, Marie-Claude [1 ]
机构
[1] Univ Manchester, Sch Canc & Enabling Sci, Wolfson Mol Imaging Ctr, Manchester M13 9PL, Lancs, England
[2] UCL, Inst Neurol, London WC1E 6BT, England
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:S169 / S170
页数:2
相关论文
共 50 条
  • [41] Dual drug interactions via P-glycoprotein (P-gp)/ cytochrome P450 (CYP3A4) interplay: recent case study of oral atorvastatin and verapamil
    Nuggehally R. Srinivas
    European Journal of Clinical Pharmacology, 2008, 64 : 1135 - 1136
  • [42] In vitro evaluation of the new P-gp tracer [18F]MC210 and comparison to (R)-[11C]verapamil
    Savolainen, Heli
    Benadiba, Marcel
    Kwizera, Chantal
    Elsinga, Philip H.
    Windhorst, Albert D.
    Lammertsma, Adriaan A.
    Cantore, Mariangela
    Colabufo, Nicola A.
    Luurtsema, Gert
    JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2013, 56 : S334 - S334
  • [43] [11C]N-Desmethyl-Loperamide is an improved radiotracer for studying brain P-gp function
    Zoghbi, Sami S.
    Liow, J. -S.
    Lazarova, N.
    Hong, J.
    Tuan, E.
    Gladding, R. L.
    Innis, R. B.
    Pike, V. W.
    NEUROIMAGE, 2008, 41 : T106 - T106
  • [44] [11C]Sorafenib: Radiosynthesis and preliminary PET study of brain uptake in P-gp/Bcrp knockout mice
    Asakawa, Chiharu
    Ogawa, Masanao
    Kumata, Katsushi
    Fujinaga, Masayuki
    Kato, Koichi
    Yamasaki, Tomoteru
    Yui, Joji
    Kawamura, Kazunori
    Hatori, Akiko
    Fukumura, Toshimitsu
    Zhang, Ming-Rong
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (08) : 2220 - 2223
  • [45] Expression and function of P-glycoprotein (P-GP) on mononuclear cells in patients with rheumatoid arthritis (RA): Comparison of cells infiltrating synovial tissue to peripheral mononuclear cells
    Jung, N.
    Barthel, U.
    Seifert, J.
    Taubert, D.
    Passon, D.
    Lehmann, C.
    Rubbert, A.
    ANNALS OF THE RHEUMATIC DISEASES, 2006, 65 : 130 - 131
  • [46] Establishment of a robust hepatitis C virus replicon cell line over-expressing P-glycoprotein that facilitates analysis of P-gp drug transporter effects on inhibitor antiviral activity
    Hernandez, Dennis
    Falk, Paul
    Yu, Fei
    Zhai, Guangzhi
    Quan, Yong
    Faria, Teresa
    Cao, Kai
    Scola, Paul
    McPhee, Fiona
    BIOCHEMICAL PHARMACOLOGY, 2013, 85 (01) : 21 - 28
  • [47] Real-time measurement of rhodamine 123 (R123) transport in T-cell subsets: Kinetics of P-glycoprotein (P-gp) function in a physiological system.
    Donnenberg, VS
    Burckart, GJ
    Nolin, TD
    Donnenberg, AD
    JOURNAL OF CLINICAL PHARMACOLOGY, 2002, 42 (09) : 1068 - 1068
  • [48] Evaluation of (R)-[11C]verapamil as PET tracer of P-glycoprotein function in the blood-brain barrier:: kinetics and metabolism in the rat
    Luurtsema, G
    Molthoff, CFM
    Schuit, RC
    Windhorst, AD
    Lammertsma, AA
    Franssen, EJF
    NUCLEAR MEDICINE AND BIOLOGY, 2005, 32 (01) : 87 - 93
  • [49] Effects of P-glycoprotein (P-GP) inhibition on the distribution of domperidone to cardiac tissue: Development of a physiologically based pharmacokinetic model in mdr1a/b(-/-) and wild type mice.
    Fenneteau, F
    Couture, L
    Nash, JA
    Turgeon, J
    Nekka, F
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2006, 79 (02) : P49 - P49
  • [50] Multidrug-resistance gene 1-type p-glycoprotein (MDR1 p-gp) inhibition by tariquidar impacts on neuroendocrine and behavioral processing of stress
    Thoeringer, Christoph K.
    Wultsch, Thomas
    Shahbazian, Anaid
    Painsipp, Evelin
    Holzer, Peter
    PSYCHONEUROENDOCRINOLOGY, 2007, 32 (8-10) : 1028 - 1040