Robust kinetic model for quantification of P-glycoprotein (P-gp) function under altered metabolism and after P-gp inhibition using (R)[C-11]verapamil and PET

被引：0

作者：

Wang, Shaonan ^{[1
]}

Feldmann, Maria ^{[2
]}

Hinz, Rainer ^{[1
]}

McMahon, Adam ^{[1
]}

Koepp, Matthias ^{[2
]}

Jackson, Alan ^{[1
]}

Asselin, Marie-Claude ^{[1
]}

机构：

[1] Univ Manchester, Sch Canc & Enabling Sci, Wolfson Mol Imaging Ctr, Manchester M13 9PL, Lancs, England

[2] UCL, Inst Neurol, London WC1E 6BT, England

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2012年 / 32卷

关键词：

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：S169 / S170

页数：2

共 50 条

[31] A Human Lymphocyte Based Ex Vivo Assay to Study the Effect of Drugs on P-glycoprotein (p-Gp) Function1
Dolly A Parasrampuria
Marianne V Lantz
Leslie Z Benet
Pharmaceutical Research, 2001, 18 : 39 - 44
[32] Development of Classification Models for Identifying "True" P-glycoprotein (P-gp) Inhibitors Through Inhibition, ATPase Activation and Monolayer Efflux Assays
Rapposelli, Simona
Coi, Alessio
Imbriani, Marcello
Bianucci, Anna Maria
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2012, 13 (06) : 6924 - 6943
[33] TRANSMEMBRANE P-GLYCOPROTEIN (P-GP/P-170) IN HIV-INFECTION - ANALYSIS OF LYMPHOCYTE SURFACE EXPRESSION AND DRUG-UNRELATED FUNCTION
LUCIA, MB
CAUDA, R
LANDAY, AL
MALORNI, W
DONELLI, G
AIDS RESEARCH AND HUMAN RETROVIRUSES, 1995, 11 (08) : 893 - 901
[34] Treatment of P-gp positive L1210/VCR cells by verapamil and ATRA induced down-regulation of P-glycoprotein expression/activity
Sulova, Z.
Macejova, D.
Seres, M.
Sedlak, J.
Gibalova, L.
Brtko, J.
Breier, A.
FEBS JOURNAL, 2007, 274 : 161 - 161
[35] Kinetic model to assess the effect of P-glycoprotein (P-gp) mediated efflux on the net pulmonary accumulation of rhodamine 6G (R6G) in the rat lung
Roerig, D
Audi, S
Ahlf, S
FASEB JOURNAL, 2005, 19 (04) : A543 - A543
[36] Exploration of analogs of [11C]dLop as potential probes for measuring increased P-gp function
Cai, Lisheng
Peng, Yiyuan
Xie, Yepeng
Hong, Jinsoo
Liow, Jeih-San
Deuitch, Lora
Hall, Matthew
Innis, Robert
Pike, Victor W.
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2015, 58 : S308 - S308
[37] P-glycoprotein (P-gp) plays a significant role in enhancing intestinal metabolism by cytochrome P450 3A4 (CYP3A4)
Cummins, CL
Benet, LZ
FASEB JOURNAL, 2001, 15 (04) : A548 - A548
[38] Evaluation of 11C-glyburide as a PET probe for P-gp and Bcrp transport imaging at the mouse BBB
Tournier, Nicolas
Saba, Wadad
Kuhnast, Bertrand
Damont, Annelaure
Dolle, Frederic
Peyronneau-Schollhorn, Marie-Anne
Valette, Heric
Cisternino, Salvatore
Bottlaender, Michel
JOURNAL OF NUCLEAR MEDICINE, 2011, 52
[39] Detection and quantification of the role of P-glycoprotein (P-gp) multidrug transporter in the uptake of rhodamine 6G (R6G) in intact rabbit lungs.
Roerig, DL
Audi, SH
Ahlf, SB
Merker, MP
Bongard, RD
Dawson, CC
FASEB JOURNAL, 2002, 16 (04) : A470 - A470
[40] Dual drug interactions via P-glycoprotein (P-gp) cytochrome P450 (CYP3A4) interplay: recent case study of oral atorvastatin and verapamil
Srinivas, Nuggehally R.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 2008, 64 (11) : 1135 - 1136

← 1 2 3 4 5 →