Synthesis of Oligosaccharide Components of the Outer Core Domain of P. aeruginosa Lipopolysaccharide Using a Multifunctional Hydroquinone-Derived Reducing-End Capping Group

被引：4

作者：

Vartak, Abhishek ^{[1
]}

Hefny, Fatma M. ^{[1
]}

Sucheck, Steven J. ^{[1
]}

机构：

[1] Univ Toledo, Dept Chem & Biochem, 2801 West Bancroft St, Toledo, OH 43606 USA

来源：

ORGANIC LETTERS | 2018年 / 20卷 / 02期

基金：

美国国家卫生研究院;

关键词：

CERIC AMMONIUM-NITRATE; MAJOR SOMATIC ANTIGENS; PSEUDOMONAS-AERUGINOSA; CHEMOENZYMATIC SYNTHESIS; VACCINE; REGION; POLYSACCHARIDE; GLYCOSYLATION; IMMUNOTYPE-5; CLEAVAGE;

D O I：

10.1021/acs.orglett.7b03590

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of a trjsaccharide (common to glycoform I and II) and a tetrasaccharOe (common to glycoform I) from the outer core domain of Pseudomonas aeruginosa lipopolysaccharide (LPS) using a novel hydroquinone-based reducing ,end capping group is reported. This multifunctional capping group was utilized as purification handle and was, stable toward many common transformations in oligosaccharide synthesis. The access to outer-core LPS antigens with a TBDPS-protected hydroquinone (TPH) at the reducing end will be useful for glycan array and therapeutic glycoconjugate synthesis.

引用

页码：353 / 356

页数：4