Aspirin enhances doxorubicin-induced apoptosis and reduces tumor growth in human hepatocellular carcinoma cells in vitro and in vivo

被引：41

作者：

Hossain, Mohammad Akbar ^{[1
]}

Kim, Dong Hwan ^{[1
]}

Jang, Jung Yoon ^{[1
]}

Kang, Yong Jung ^{[1
]}

Yoon, Jeong-Hyun ^{[1
]}

Moon, Jeon-Ok ^{[1
]}

Chung, Hae Young ^{[1
]}

Kim, Gi-Young ^{[2
]}

Choi, Yung Hyun ^{[3
]}

Copple, Bryan L. ^{[4
]}

Kim, Nam Deuk ^{[1
]}

机构：

[1] Pusan Natl Univ, Coll Pharm, Dept Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA,Div Ph, Pusan 609735, South Korea

[2] Jeju Natl Univ, Fac Appl Marine Sci, Cheju 690756, South Korea

[3] Dong Eui Univ, Grad Sch, Dept Biomat Control, Program BK21, Pusan 614052, South Korea

[4] Michigan State Univ, Dept Pharmacol & Toxicol, E Lansing, MI 48824 USA

来源：

INTERNATIONAL JOURNAL OF ONCOLOGY | 2012年 / 40卷 / 05期

关键词：

aspirin; doxorubicin; hepatocellular carcinoma; apoptosis; xenograft model; COLORECTAL-CANCER; CHEMOTHERAPY; MODULATION; ACTIVATION; SALICYLATE; EXPRESSION; CASPASES; DRUGS;

D O I：

10.3892/ijo.2012.1359

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Combined therapy with multiple drugs is a common practice in the treatment of cancer, which can achieve better therapeutic effects than a single drug, and can reduce the side effects as well as drug resistance. This study aimed to determine whether aspirin (ASA) shows synergism with doxorubicin (DOX) in HepG2 human hepatocellular carcinoma cells in vitro and in a HepG2 cell xenograft model in BALB/c nude mice. When treated in combination, DOX (0.25 nmol/ml) and ASA (5 mu mol/ml) produced strong synergy in growth inhibition, cell cycle arrest and importantly, apoptosis in vitro in comparison to single treatments. Moreover, ASA (100 mg/kg/day orally) and DOX (1.2 mg/kg biweekly ip) induced synergistic antitumor activity in the HepG2 cell xenograft model in nude mice. Therefore, the combination of ASA and DOX could be used as a novel combination regimen which provides a strong anticancer synergy in the treatment of hepatocellular carcinoma.

引用

页码：1636 / 1642

页数：7

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