Role of Placental VDR Expression and Function in Common Late Pregnancy Disorders

被引：46

作者：

Knabl, Julia ^{[1
,2
]}

Vattai, Aurelia ^{[1
]}

Ye, Yao ^{[1
]}

Jueckstock, Julia ^{[1
]}

Hutter, Stefan ^{[1
]}

Kainer, Franz ^{[2
]}

Mahner, Sven ^{[1
]}

Jeschke, Udo ^{[1
]}

机构：

[1] Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Obstet & Gynecol, D-80337 Munich, Germany

[2] Klin Hallerwiese, Dept Obstet & Gynecol, D-90419 Nurnberg, Germany

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2017年 / 18卷 / 11期

关键词：

vitamin D; VDR; preterm birth; GDM; preeclampsia; fetal growth restriction; VITAMIN-D-RECEPTOR; GESTATIONAL DIABETES-MELLITUS; 25-HYDROXYVITAMIN D-3 1-ALPHA-HYDROXYLASE; INTRAUTERINE GROWTH RESTRICTION; IMPAIRED GLUCOSE-TOLERANCE; CYTOKINE-INDUCED APOPTOSIS; SPONTANEOUS PRETERM BIRTH; CALCIUM-BINDING PROTEIN; 1,25-DIHYDROXYVITAMIN D-3; D DEFICIENCY;

D O I：

10.3390/ijms18112340

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Vitamin D, besides its classical role in bone metabolism, plays a distinct role in multiple pathways of the feto-maternal unit. Calcitriol is the major active ligand of the nuclear vitamin D receptor (VDR). The vitamin D receptor (VDR) is expressed in different uteroplacental parts and exerts a variety of functions in physiologic pregnancy. It regulates decidualisation and implantation, influences hormone secretion and placental immune modulations. This review highlights the role of the vitamin D receptor in physiologic and disturbed pregnancy, as preeclampsia, fetal growth restriction, gestational diabetes and preterm birth. We discuss the existing literature regarding common VDR polymorphisms in these pregnancy disorders.

引用

页数：18

共 178 条

[1]

Aghajafari F., 2013, BMJ (Clinical research edition), V346, pf1169, DOI DOI 10.1136/BMJ.F1169

[2] Maternal vitamin D insufficiency and risk of adverse pregnancy and birth outcomes: A systematic review and meta-analysis of longitudinal studies [J].

Amegah, A. Kofi ;

Klevor, Moses K. ;

Wagner, Carol L. .

PLOS ONE, 2017, 12 (03)

[3] VDR FokI polymorphism and its potential role in the pathogenesis of gestational diabetes mellitus and its complications [J].

Aslani, Shilan ;

Hossein-Nezhad, Arash ;

Mirzaei, Khadijeh ;

Maghbooli, Zhila ;

Afshar, Azam Najm ;

Karimi, Farzaneh .

GYNECOLOGICAL ENDOCRINOLOGY, 2011, 27 (12) :1055-1060

[4] ABNORMAL 1,25-DIHYDROXYVITAMIN-D METABOLISM IN PREECLAMPSIA [J].

AUGUST, P ;

MARCACCIO, B ;

GERTNER, JM ;

DRUZIN, ML ;

RESNICK, LM ;

LARAGH, JH .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1992, 166 (04) :1295-1299

[5] Regulation of 25-hydroxyvitamin D3 1α-hydroxylase, 1,25-dihydroxyvitamin D3 24-hydroxylase and vitamin D receptor gene expression by 8-bromo cyclic AMP in cultured human syncytiotrophoblast cells [J].

Avila, E ;

Díaz, L ;

Halhali, A ;

Larrea, F .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2004, 89-90 (1-5) :115-119

[6] Regulation of Vitamin D hydroxylases gene expression by 1,25-dihydroxyvitamin D3 and cyclic AMP in cultured human syncytiotrophoblasts [J].

Avila, Euclides ;

Diaz, Lorenza ;

Barrera, David ;

Halhali, Ali ;

Mendez, Isabel ;

Gonzalez, Leticia ;

Zuegel, Ulrich ;

Steinmeyer, Andreas ;

Larrea, Fernando .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2007, 103 (01) :90-96

[7] Influence of Apa1 (rs7975232), Taq1 (rs731236) and Bsm1 (rs154410) polymorphisms of vitamin D receptor on preterm birth risk in the Polish population [J].

Baczynska-Strzecha, Marta ;

Kalinka, Jaroslaw .

GINEKOLOGIA POLSKA, 2016, 87 (11) :763-768

[8] First-trimester maternal vitamin D status and risk for gestational diabetes (GDM) a nested case-control study [J].

Baker, Arthur M. ;

Haeri, Sina ;

Camargo, Carlos A., Jr. ;

Stuebe, Alison M. ;

Boggess, Kim A. .

DIABETES-METABOLISM RESEARCH AND REVIEWS, 2012, 28 (02) :164-168

[9] A Nested Case-Control Study of Midgestation Vitamin D Deficiency and Risk of Severe Preeclampsia [J].

Baker, Arthur M. ;

Haeri, Sina ;

Camargo, Carlos A., Jr. ;

Espinola, Janice A. ;

Stuebe, Alison M. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2010, 95 (11) :5105-5109

[10] Fetal origins of adult disease:: strength of effects and biological basis [J].

Barker, DJP ;

Eriksson, JG ;

Forsén, T ;

Osmond, C .

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2002, 31 (06) :1235-1239

← 1 2 3 4 5 6 7 8 9 10 →