Enantioselective protonation of samarium enolates derived from α-heterosubstituted ketones and lactone by SmI2-mediated reduction

被引：51
作者：
Nakamura, Y
Takeuchi, S
Ohgo, Y
Yamaoka, M
Yoshida, A
Mikami, K
机构：
[1] Niigata Coll Pharm, Niigata 9502081, Japan
[2] Tokyo Inst Technol, Dept Chem Technol, Meguro Ku, Tokyo 152, Japan
来源：
TETRAHEDRON | 1999年 / 55卷 / 15期
关键词：
D O I：
10.1016/S0040-4020(99)00143-X
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
SmI2-mediated reductive cleavage of alpha-hetero substituents of alpha-alkyl or alpha-aryl ketones and lactone gave the corresponding "thermodynamic samarium enolates". Enantioselective protonation of the samarium enolates with C-2-symmetric chiral diets afforded the corresponding ketones and lactone in moderate to high enantioselectivities. (C) 1999 Elsevier Science Ltd. All rights reserved.
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页码：4595 / 4620
页数：26
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