Anti-HIV-1 constituents from Clausena excavata:: Part II.: Carbazoles and a pyranocoumarin

被引：90

作者：

Kongkathip, B ^{[1
]}

Kongkathip, N

Sunthitikawinsakul, A

Napaswat, C

Yoosook, C

机构：

[1] Kasetsart Univ, Fac Sci, Dept Chem, Nat Prod & Organ Synth Res Unit, Bangkok 10900, Thailand

[2] Mahidol Univ, Fac Sci, Dept Microbiol, Bangkok 10400, Thailand

来源：

PHYTOTHERAPY RESEARCH | 2005年 / 19卷 / 08期

关键词：

Clausena excavata; Rutaceae; carbazole; pyranocoumarin; coumarin; anti-HIV-1; activity;

D O I：

10.1002/ptr.1738

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three carbazole derivatives, O-methylmukonal (1), 3-formyl-2,7-dimethoxycarbazole (2) and clauszoline J (3), and a pyranocoumarin, clausenidin (4), were isolated from the rhizomes and roots of Clausena excavata. Compound 1, isolated from this plant for the first time, has not been reported previously as having anti-HIV-1 activity. Compounds 1-4 displayed anti-HIV-1 activity in a syncytial assay with EC50 values of 12, 29.1, 34.2 and 5.3 mu m, respectively, and thus exhibited potential therapeutic index (PTI) values of 56.7, 8.0, 1.6 and 7.0, respectively. All isolated compounds demonstrated a lack of cytotoxicity against the KB and BC-1 cancer cell lines. Copyright (c) 2005 John Wiley & Sons, Ltd.

引用

页码：728 / 731

页数：4

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