Genetic variation in complement regulators and susceptibility to age-related macular degeneration

被引:19
作者
Cipriani, Valentina [1 ,2 ]
Matharu, Baljinder K. [3 ]
Khan, Jane C. [3 ]
Shahid, Humma [3 ]
Stanton, Chloe M.
Hayward, Caroline [4 ]
Wright, Alan F. [4 ]
Bunce, Catey [2 ]
Clayton, David G. [3 ]
Moore, Anthony T. [2 ]
Yates, John R. W. [2 ,3 ]
机构
[1] UCL, Inst Ophthalmol, Dept Genet, London EC1V 9EL, England
[2] Moorfields Eye Hosp, London, England
[3] Univ Cambridge, Cambridge Inst Med Res, Dept Med Genet, Cambridge CB2 1TN, England
[4] Inst Genet & Mol Med, MRC, Human Genet Unit, Edinburgh, Midlothian, Scotland
基金
英国医学研究理事会; 英国惠康基金;
关键词
Age-related macular degeneration; Complement; Complement regulators; Genetic association; Genetic variation; Single nucleotide polymorphism; FACTOR-H POLYMORPHISM; ASSOCIATION; RISK; PROTEINS; ACTIVATION; HAPLOTYPE; DISEASE; SYSTEM; COMMON; ROLES;
D O I
10.1016/j.imbio.2011.09.002
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Objectives: Age-related macular degeneration (AMD) is the commonest cause of blindness in Western populations. Risk is influenced by age, genetic and environmental factors. Complement activation appears to be important in the pathogenesis and associations have been found between AMD and genetic variations in complement regulators such as complement factor H. We therefore investigated other complement regulators for association with AMD. Methods: We carried out a case-control study to test for association between AMD and single nucleotide polymorphisms (SNPs) spanning the genes encoding complement factor P (CFP, properdin), CD46 (membrane cofactor protein, MCP), CD55 (decay accelerating factor, OAF) and CD59 (protectin). All cases and controls were examined by an ophthalmologist and had independent grading of fundus photographs to confirm their disease status. Results: 20 SNPs were genotyped in 446 cases and 262 controls. For two SNPs with p-values approaching significance additional subjects were genotyped to increase the numbers to 622 cases and 359 controls. There was no evidence of association between AMD and any of the SNPs typed in CFP, CD46, CD55 or CD59. Conclusions: In a case-control sample that has shown the well established associations between AMD and variants in CFH, CFB and C3 there was absence of association with SNPs in CFP, CD46, CD55 and CD59. This suggests that these are not important susceptibility genes for AMD. (C) 2011 Elsevier GmbH. All rights reserved.
引用
收藏
页码:158 / 161
页数:4
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