A New Target for Therapy in Squamous Cell Carcinoma of the Lung

被引：10

作者：

Ohashi, Kadoaki ^{[1
]}

Pao, William ^{[1
]}

机构：

[1] Vanderbilt Ingram Canc Ctr, Dept Med, Nashville, TN 37232 USA

来源：

CANCER DISCOVERY | 2011年 / 1卷 / 01期

关键词：

MUTATIONS; CANCER;

D O I：

10.1158/2159-8274.CD-11-0069

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Investigators report the identification of novel somatic mutations in the DDR2 kinase gene in squamous cell carcinoma of the lung. Cellular, biochemical, and human data suggest that tumor cells harboring DDR2 mutations have increased sensitivity to existing tyrosine kinase inhibitors, providing rationale for clinical trials of agents that inhibit DDR2 kinase in the disease. Cancer Discovery; 1(1); 23-4. (C) 2011 AACR.

引用

页码：23 / 24

页数：2

共 12 条

[1]

*CANC GEN ATL, 2006, LUNG SQUAM CELL CARC

[2] Somatic mutations of the protein kinase gene family in human lung cancer [J].

Davies, H ;

Hunter, C ;

Smith, R ;

Stephens, P ;

Greenman, C ;

Bignell, G ;

Teague, B ;

Butler, A ;

Edkins, S ;

Stevens, C ;

Parker, A ;

O'Meara, S ;

Avis, T ;

Barthorpe, S ;

Brackenbury, L ;

Buck, G ;

Clements, B ;

Cole, J ;

Dicks, E ;

Edwards, K ;

Forbes, S ;

Gorton, M ;

Gray, K ;

Halliday, K ;

Harrison, R ;

Hills, K ;

Hinton, J ;

Jones, D ;

Kosmidou, V ;

Laman, R ;

Lugg, R ;

Menzies, A ;

Perry, J ;

Petty, R ;

Raine, K ;

Shepherd, R ;

Small, A ;

Solomon, H ;

Stephens, Y ;

Tofts, C ;

Varian, J ;

Webb, A ;

West, S ;

Widaa, S ;

Yates, A ;

Brasseur, F ;

Cooper, CS ;

Flanagan, AM ;

Green, A ;

Knowles, M .

CANCER RESEARCH, 2005, 65 (17) :7591-7595

[3]

Hammerman PS, 2011, CANCER DISCOV, V1, pOF76

[4] Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase inhibitors [J].

Ji, Hongbin ;

Zhao, Xiaojun ;

Yuza, Yuki ;

Shimamura, Takeshi ;

Li, Danan ;

Protopopov, Alexei ;

Jung, Boonim L. ;

McNamara, Kate ;

Xia, Huili ;

Glatt, Karen A. ;

Thomas, Roman K. ;

Sasaki, Hidefumi ;

Horner, James W. ;

Eck, Michael ;

Mitchell, Albert ;

Sun, Yangping ;

Al-Hashem, Ruqayyah ;

Bronson, Roderick T. ;

Rabindran, Sriclhar K. ;

Discafani, Carolyn M. ;

Maher, Elizabeth ;

Shapiro, Geoffrey I. ;

Meyerson, Matthew ;

Wong, Kwok-Kin .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (20) :7817-7822

[5] Phase II Study of Dasatinib in Patients With Advanced Non-Small-Cell Lung Cancer [J].

Johnson, Faye M. ;

Bekele, B. Nebiyou ;

Feng, Lei ;

Wistuba, Ignacio ;

Tang, Xi Ming ;

Tran, Hai T. ;

Erasmus, Jeremy J. ;

Hwang, Li-Ling ;

Takebe, Naoko ;

Blumenschein, George R. ;

Lippman, Scott M. ;

Stewart, David J. .

JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (30) :4609-4615

[6] The Evolving Role of Histology in the Management of Advanced Non-Small-Cell Lung Cancer [J].

Langer, Corey J. ;

Besse, Benjamin ;

Gualberto, Antonio ;

Brambilla, Elizabeth ;

Soria, Jean-Charles .

JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (36) :5311-5320

[7] Significance of epidermal growth factor receptor gene mutations in squamous cell lung carcinoma [J].

Miyamae, Yohei ;

Shimizu, Kimihiro ;

Hirato, Junko ;

Araki, Takuya ;

Tanaka, Kazumi ;

Ogawa, Hiroomi ;

Kakegawa, Seiichi ;

Sugano, Masayuki ;

Nakano, Tetsuhiro ;

Mitani, Yasumasa ;

Kaira, Kyoichi ;

Takeyoshi, Izumi .

ONCOLOGY REPORTS, 2011, 25 (04) :921-928

[8] Genetically informed lung cancer medicine [J].

Pao, William ;

Iafrate, A. John ;

Su, Zengliu .

JOURNAL OF PATHOLOGY, 2011, 223 (02) :230-240

[9] Characterizing the cancer genome in lung adenocarcinoma [J].

Weir, Barbara A. ;

Woo, Michele S. ;

Getz, Gad ;

Perner, Sven ;

Ding, Li ;

Beroukhim, Rameen ;

Lin, William M. ;

Province, Michael A. ;

Kraja, Aldi ;

Johnson, Laura A. ;

Shah, Kinjal ;

Sato, Mitsuo ;

Thomas, Roman K. ;

Barletta, Justine A. ;

Borecki, Ingrid B. ;

Broderick, Stephen ;

Chang, Andrew C. ;

Chiang, Derek Y. ;

Chirieac, Lucian R. ;

Cho, Jeonghee ;

Fujii, Yoshitaka ;

Gazdar, Adi F. ;

Giordano, Thomas ;

Greulich, Heidi ;

Hanna, Megan ;

Johnson, Bruce E. ;

Kris, Mark G. ;

Lash, Alex ;

Lin, Ling ;

Lindeman, Neal ;

Mardis, Elaine R. ;

McPherson, John D. ;

Minna, John D. ;

Morgan, Margaret B. ;

Nadel, Mark ;

Orringer, Mark B. ;

Osborne, John R. ;

Ozenberger, Brad ;

Ramos, Alex H. ;

Robinson, James ;

Roth, Jack A. ;

Rusch, Valerie ;

Sasaki, Hidefumi ;

Shepherd, Frances ;

Sougnez, Carrie ;

Spitz, Margaret R. ;

Tsao, Ming-Sound ;

Twomey, David ;

Verhaak, Roel G. W. ;

Weinstock, George M. .

NATURE, 2007, 450 (7171) :893-U22

[10] Frequent and Focal FGFR1 Amplification Associates with Therapeutically Tractable FGFR1 Dependency in Squamous Cell Lung Cancer [J].

Weiss, Jonathan ;

Sos, Martin L. ;

Seidel, Danila ;

Peifer, Martin ;

Zander, Thomas ;

Heuckmann, Johannes M. ;

Ullrich, Roland T. ;

Menon, Roopika ;

Maier, Sebastian ;

Soltermann, Alex ;

Moch, Holger ;

Wagener, Patrick ;

Fischer, Florian ;

Heynck, Stefanie ;

Koker, Mirjam ;

Schoettle, Jakob ;

Leenders, Frauke ;

Gabler, Franziska ;

Dabow, Ines ;

Querings, Silvia ;

Heukamp, Lukas C. ;

Balke-Want, Hyatt ;

Ansen, Sascha ;

Rauh, Daniel ;

Baessmann, Ingelore ;

Altmueller, Janine ;

Wainer, Zoe ;

Conron, Matthew ;

Wright, Gavin ;

Russell, Prudence ;

Solomon, Ben ;

Brambilla, Elisabeth ;

Brambilla, Christian ;

Lorimier, Philippe ;

Sollberg, Steinar ;

Brustugun, Odd Terje ;

Engel-Riedel, Walburga ;

Ludwig, Corinna ;

Petersen, Iver ;

Saenger, Joerg ;

Clement, Joachim ;

Groen, Harry ;

Timens, Wim ;

Sietsma, Hannie ;

Thunnissen, Erik ;

Smit, Egbert ;

Heideman, Danielle ;

Cappuzzo, Federico ;

Ligorio, Claudia ;

Damiani, Stefania .

SCIENCE TRANSLATIONAL MEDICINE, 2010, 2 (62)

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