Conjugated linoleic acid increased C-reactive protein in human subjects

被引：60

作者：

Smedman, A ^{[1
]}

Basu, S

Jovinge, S

Fredrikson, GN

Vessby, B

机构：

[1] Uppsala Univ, Dept Publ Hlth & Caring Sci, Clin Nutr Res Unit, Uppsala, Sweden

[2] Lund Univ, Univ Hosp MAS, Dept Med Cardiol, Malmo, Sweden

来源：

BRITISH JOURNAL OF NUTRITION | 2005年 / 94卷 / 05期

关键词：

conjugated linoleic acid; C-reactive protein; tumour necrosis factor-alpha; inflammation;

D O I：

10.1079/BJN20041419

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

We previously showed that conjugated linoleic acid (CLA) increases 15-keto-dihydro-prostaglandin F-2 alpha, a marker for cyclooxygenase-mediated lipid peroxidation and thus an indicator of cyclooxygenase-mediated inflammation. The aim of the present study was to investigate the effects of CLA on other indicators of inflammation in human subjects, including C-reactive protein, TNF-alpha, TNF-alpha receptors 1 and 2, and vascular cell adhesion molecule-1. In a double-blind, placebo-controlled study, fifty-three human subjects were supplemented with a mixture (4.2 g/d) of the isomers cis-9,trans-11 CLA and trans-10,cis-12 CLA or control oil for 3 months. CLA supplementation increased levels of C-reactive protein (P=0.003) compared with the control group. However, no changes in TNF-alpha, TNF-alpha receptors 1 and 2, and vascular cell adhesion molecule-1 were detected.

引用

页码：791 / 795

页数：5

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