New directions in poly(ADP-ribose) polymerase biology

被引：61
作者：
Bock, Florian J. [1 ,2 ]
Chang, Paul [3 ]
机构：
[1] Canc Res UK Beatson Inst, Garscube Estate, Glasgow, Lanark, Scotland
[2] Univ Glasgow, Inst Canc Sci, Garscube Estate, Glasgow, Lanark, Scotland
[3] Ribon Therapeut, Lexington, MA 02421 USA
来源：
FEBS JOURNAL | 2016年 / 283卷 / 22期
关键词：
ADP-ribosylation; poly(ADP-ribose) polymerases; post-translational modification; stress response; NF-KAPPA-B; ADP-RIBOSYLTRANSFERASE ARTD10; PROTEOME-WIDE IDENTIFICATION; DNA STRAND BREAKS; RNA REGULATION; STRESS RESPONSES; MAMMALIAN-CELLS; ES CELLS; T-CELLS; RIBOSE;
D O I：
10.1111/febs.13737
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Poly(ADP-ribose) polymerases (PARPs) regulate the function of target proteins by modifying them with ADP-ribose, a large and unique post-translational modification. Humans express 17 PARPs; however, historically, much of the focus has been on PARP1 and its function in DNA damage repair. Recent work has uncovered an amazing diversity of function for these enzymes including the regulation of fundamental physiological processes in the cell and at the organismal level, as well as new roles in regulating cellular stress responses. In this review, we discuss recent advancements in our understanding of this important protein family, and technological developments that have been critical for moving the field forward. Finally, we discuss new directions that we feel are important areas of further scientific exploration.
引用
收藏
页码：4017 / 4031
页数：15
相关论文
共 103 条
  • [1] Poly(ADP-ribose)-Dependent Regulation of DNA Repair by the Chromatin Remodeling Enzyme ALC1
    Ahel, Dragana
    Horejsi, Zuzana
    Wiechens, Nicola
    Polo, Sophie E.
    Garcia-Wilson, Elisa
    Ahel, Ivan
    Flynn, Helen
    Skehel, Mark
    West, Stephen C.
    Jackson, Stephen P.
    Owen-Hughes, Tom
    Boulton, Simon J.
    [J]. SCIENCE, 2009, 325 (5945) : 1240 - 1243
  • [2] Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose)
    Altmeyer, Matthias
    Neelsen, Kai J.
    Teloni, Federico
    Pozdnyakova, Irina
    Pellegrino, Stefania
    Grofte, Merete
    Rask, Maj-Britt Druedahl
    Streicher, Werner
    Jungmichel, Stephanie
    Nielsen, Michael Lund
    Lukas, Jiri
    [J]. NATURE COMMUNICATIONS, 2015, 6
  • [3] Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis
    Andrabi, Shaida A.
    Umanah, George K. E.
    Chang, Calvin
    Stevens, Daniel A.
    Karuppagounder, Senthilkumar S.
    Gagne, Jean-Philippe
    Poirier, Guy G.
    Dawson, Valina L.
    Dawson, Ted M.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (28) : 10209 - 10214
  • [4] Formation of stress granules inhibits apoptosis by suppressing stress-responsive MAPK pathways
    Arimoto, Kyoko
    Fukuda, Hiroyuki
    Imajoh-Ohmi, Shinobu
    Saito, Haruo
    Takekawa, Mutsuhiro
    [J]. NATURE CELL BIOLOGY, 2008, 10 (11) : 1324 - U167
  • [5] Peroxisome proliferator-activated receptor (PPAR)-2 controls adipocyte differentiation and adipose tissue function through the regulation of the activity of the retinoid x receptor/PPARγ heterodimer
    Bai, Peter
    Houten, Sander M.
    Huber, Aline
    Schreiber, Valerie
    Watanabe, Mitsuhiro
    Kiss, Borbala
    de Murcia, Gilbert
    Auwerx, Johan
    Menissier-de Murcia, Josiane
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (52) : 37738 - 37746
  • [6] Poly(ADP-ribose) polymerases as modulators of mitochondrial activity
    Bai, Peter
    Nagy, Lille
    Fodor, Tamas
    Liaudet, Lucas
    Pacher, Pal
    [J]. TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2015, 26 (02) : 75 - 83
  • [7] PARP-2 Regulates SIRT1 Expression and Whole-Body Energy Expenditure
    Bai, Peter
    Canto, Carles
    Brunyanszki, Attila
    Huber, Aline
    Szanto, Magdolna
    Cen, Yana
    Yamamoto, Hiroyasu
    Houten, Sander M.
    Kiss, Borbala
    Oudart, Hugues
    Gergely, Pal
    Menissier-de Murcia, Josiane
    Schreiber, Valerie
    Sauve, Anthony A.
    Auwerx, Johan
    [J]. CELL METABOLISM, 2011, 13 (04) : 450 - 460
  • [8] PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation
    Bai, Peter
    Canto, Caries
    Oudart, Hugues
    Brunyanszki, Attila
    Cen, Yana
    Thomas, Charles
    Yamamoto, Hiroyasu
    Huber, Aline
    Kiss, Borbala
    Houtkooper, Riekelt H.
    Schoonjans, Kristina
    Schreiber, Valerie
    Sauve, Anthony A.
    Menissier-de Murcia, Josiane
    Auwerx, Johan
    [J]. CELL METABOLISM, 2011, 13 (04) : 461 - 468
  • [9] Visualization of poly(ADP-ribose) bound to PARG reveals inherent balance between exo- and endo-glycohydrolase activities
    Barkauskaite, Eva
    Brassington, Amy
    Tan, Edwin S.
    Warwicker, Jim
    Dunstan, Mark S.
    Banos, Benito
    Lafite, Pierre
    Ahel, Marijan
    Mitchison, Timothy J.
    Ahel, Ivan
    Leys, David
    [J]. NATURE COMMUNICATIONS, 2013, 4
  • [10] Poly(ADP-ribose) polymerases in double-strand break repair: Focus on PARP1, PARP2 and PARP3
    Beck, Carole
    Robert, Isabelle
    Reina-San-Martin, Bernardo
    Schreiber, Valerie
    Dantzer, Francoise
    [J]. EXPERIMENTAL CELL RESEARCH, 2014, 329 (01) : 18 - 25
12345678910