New directions in poly(ADP-ribose) polymerase biology

被引：61

作者：

Bock, Florian J. ^{[1
,2
]}

Chang, Paul ^{[3
]}

机构：

[1] Canc Res UK Beatson Inst, Garscube Estate, Glasgow, Lanark, Scotland

[2] Univ Glasgow, Inst Canc Sci, Garscube Estate, Glasgow, Lanark, Scotland

[3] Ribon Therapeut, Lexington, MA 02421 USA

来源：

FEBS JOURNAL | 2016年 / 283卷 / 22期

关键词：

ADP-ribosylation; poly(ADP-ribose) polymerases; post-translational modification; stress response; NF-KAPPA-B; ADP-RIBOSYLTRANSFERASE ARTD10; PROTEOME-WIDE IDENTIFICATION; DNA STRAND BREAKS; RNA REGULATION; STRESS RESPONSES; MAMMALIAN-CELLS; ES CELLS; T-CELLS; RIBOSE;

D O I：

10.1111/febs.13737

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Poly(ADP-ribose) polymerases (PARPs) regulate the function of target proteins by modifying them with ADP-ribose, a large and unique post-translational modification. Humans express 17 PARPs; however, historically, much of the focus has been on PARP1 and its function in DNA damage repair. Recent work has uncovered an amazing diversity of function for these enzymes including the regulation of fundamental physiological processes in the cell and at the organismal level, as well as new roles in regulating cellular stress responses. In this review, we discuss recent advancements in our understanding of this important protein family, and technological developments that have been critical for moving the field forward. Finally, we discuss new directions that we feel are important areas of further scientific exploration.

引用

页码：4017 / 4031

页数：15

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