Plasma disposition, concentration in the hair, and anthelmintic efficacy of eprinomectin after topical administration in donkeys

被引:10
作者
Gokbulut, Cengiz [1 ]
Di Loria, Antonio [3 ]
Gunay, Necati [2 ]
Masucci, Roberto [5 ]
Veneziano, Vincenzo [4 ]
机构
[1] Univ Adnan Menderes, Fac Vet Med, Dept Pharmacol & Toxicol, TR-09100 Isikli Koyu, Aydin, Turkey
[2] Univ Adnan Menderes, ADUBILTEM Res & Dev Ctr, TR-09100 Isikli Koyu, Aydin, Turkey
[3] Univ Naples Federico 2, Fac Vet Med, Dept Vet Clin Sci, I-80138 Naples, Italy
[4] Univ Naples Federico 2, Fac Vet Med, Dept Pathol & Anim Hlth, I-80138 Naples, Italy
[5] Clin Nuovi Orizzonti, I-81030 Caserta, Italy
关键词
LACTATING DAIRY-CATTLE; POUR-ON; PHARMACOKINETIC PARAMETERS; IVERMECTIN EQVALAN(R); FECAL EXCRETION; HORSES; MILK; DORAMECTIN; SHEEP; MOXIDECTIN;
D O I
10.2460/ajvr.72.12.1639
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Objective-To investigate plasma disposition, concentration in the hair, and anthelmintic efficacy of eprinomectin after topical administration in donkeys. Animals-12 donkeys naturally infected with strongyle nematodes. Procedures-The pour-on formulation of eprinomectin approved for use in cattle was administered topically to donkeys at a dosage of 0.5 mg/kg. Heparinized blood samples and hair samples were collected at various times between 1 hour and 40 days after administration. Samples were analyzed via high-performance liquid chromatography with fluorescence detection. Fecal strongyle egg counts were performed by use of a modified McMaster technique before and at weekly intervals for 8 weeks after treatment. Results-Plasma concentration and systemic availability of eprinomectin were relatively higher in donkeys, compared with values reported for other animal species. Concerning the anthelmintic efficacy against strongyle nematodes, eprinomectin was completely effective (100%) on days 7 and 14 and highly effective (>99%) until the end of the study at 56 days after treatment. No abnormal clinical signs or adverse reactions were observed for any donkeys after treatment. Conclusions and Clinical Relevance-Eprinomectin had excellent safety. The relatively high plasma concentration after topical administration could result in use of eprinomectin for the control and treatment of parasitic diseases in donkeys. (Am J Vet Res 2011;72:1639-1645)
引用
收藏
页码:1639 / 1645
页数:7
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