Amino acid substitution within the VP7 protein of G2 rotavirus strains associated with failure to serotype

被引：116

作者：

Gómara, MI

Cubitt, D

Desselberger, U

Gray, J

机构：

[1] Addenbrookes Hosp, Clin Microbiol & Publ Hlth Lab, Cambridge CB2 2QW, England

[2] Great Ormond St Hosp Sick Children, Camelia Botnar Labs, London WC1N 3JH, England

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2001年 / 39卷 / 10期

关键词：

D O I：

10.1128/JCM.39.10.3796-3798.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Rotavirus strains collected in the United Kingdom during the 1995-1996 season and genotyped as G2 by reverse transcription-PCR failed to serotype in enzyme-linked immunosorbent assays using three different G2-specific monoclonal antibodies. The deduced amino acid sequences of the antigenic regions A (amino acids 87 to 101), B (amino acids 142 to 152), and C (amino acids 208 to 221) of VP7 revealed that a substitution at position 96 (Asp --> Asn) correlated with the change in ability to serotype these G2 strains.

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页码：3796 / 3798

页数：3

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