Relationship between perioperative oncological evaluation and recurrence using circulating tumor DNA with KRAS mutation in patients with colorectal cancer

被引:2
作者
Hayashi, Takaomi [1 ]
Yoshida, Yoichiro [1 ]
Yamada, Teppei [1 ]
Tanaka, Keita [1 ]
Shimaoka, Hideki [1 ]
Kajitani, Ryuji [1 ]
Munechika, Taro [1 ]
Nagano, Hideki [1 ]
Matsumoto, Yoshiko [1 ]
Komono, Akira [1 ]
Sakamoto, Ryohei [1 ]
Aisu, Naoya [1 ]
Yoshimatsu, Gumpei [1 ]
Yoshimura, Fumihiro [1 ]
Hasegawa, Suguru [1 ]
机构
[1] Fukuoka Univ, Dept Gastroenterol Surg, Fac Med, Fukuoka, Japan
来源
CANCER MEDICINE | 2022年 / 11卷 / 16期
关键词
circulating tumor DNA; colorectal cancer; digital PCR; KRAS; liquid biopsy; PROGNOSTIC VALUE; CELLS; PLASMA; SERUM;
D O I
10.1002/cam4.4677
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background The detection of circulating tumor DNA (ctDNA) in colorectal cancer (CRC) by liquid biopsy may have prognostic information. In this perioperative study, we evaluate if there is a relationship between mutant allele frequency (MAF) of Kirsten rat sarcoma viral oncogene homolog (KRAS) and tumor recurrence and how that could be useful in the early detection of recurrence. Methods Among 304 cases of colorectal cancer surgery, ctDNA was sampled from the perioperative blood of 84 patients with CRC with KRAS mutation (exon 4 p.A146T, exon 4 p.A146V, exon 2 p.G12A, exon 2 p.G12C, exon 2 p.G12D, exon 2 p.G12S, exon 2 p.G12V, exon 2 p.G13D, exon 3 p.Q61H) and analyzed using the digital polymerase chain reaction system. The median observation period was 26 months. Results Although the relationship between the perioperative MAF of KRAS and recurrence was not proved, tumor diameter, tumor depth, and stage were correlated with the preoperative MAF of KRAS (p = 0.034, p = 0.002, p = 0.008). However, tumor diameter, tumor depth, and stage did not correlate with MAF of KRAS at postoperative day 30. Conclusions In this study, pathological tumor size, tumor depth, and stage were correlated with preoperative MAF of KRAS, but it was unreliable to predict recurrence by detection of ctDNA with KRAS mutation in the perioperative period of colorectal surgery.
引用
收藏
页码:3126 / 3135
页数:10
相关论文
共 50 条
[31]   Tumor-infiltrating lymphocytes and dendritic cells in human colorectal cancer: Their relationship to KRAS mutational status and disease recurrence [J].
Kocian, Petr ;
Sedivcova, Monika ;
Drgac, Jan ;
Cerna, Katerina ;
Hoch, Jiri ;
Kodet, Roman ;
Bartunkova, Jirina ;
Spisek, Radek ;
Fialova, Anna .
HUMAN IMMUNOLOGY, 2011, 72 (11) :1022-1028
[32]   Association between autophagy and KRAS mutation with clinicopathological variables in colorectal cancer patients [J].
Awi, Noel Jacques ;
Yap, Hooi-Yeen ;
Armon, Subasri ;
Low, John Seng-Hooi ;
Peh, Kaik-Boo ;
Peh, Suat-Cheng ;
Lee, C. Soon ;
Teow, Sin-Yeang .
MALAYSIAN JOURNAL OF PATHOLOGY, 2021, 43 (02) :269-279
[33]   Comparison of KRAS mutation status between primary tumor and metastasis in Chinese colorectal cancer patients [J].
Li, Zhe-Zhen ;
Bai, Long ;
Wang, Feng ;
Zhang, Zi-Chen ;
Wang, Fang ;
Zeng, Zhao-Lei ;
Zeng, Jun-Bo ;
Zhang, Dong-Sheng ;
Wang, Feng-Hua ;
Wang, Zhi-Qiang ;
Li, Yu-Hong ;
Shao, Jian-Yong ;
Xu, Rui-Hua .
MEDICAL ONCOLOGY, 2016, 33 (07)
[34]   Comparison of KRAS mutation status between primary tumor and metastasis in Chinese colorectal cancer patients [J].
Zhe-Zhen Li ;
Long Bai ;
Feng Wang ;
Zi-Chen Zhang ;
Fang Wang ;
Zhao-Lei Zeng ;
Jun-Bo Zeng ;
Dong-Sheng Zhang ;
Feng-Hua Wang ;
Zhi-Qiang Wang ;
Yu-Hong Li ;
Jian-Yong Shao ;
Rui-Hua Xu .
Medical Oncology, 2016, 33
[35]   Correlation between circulating tumor DNA and carcinoembryonic antigen levels in patients with metastatic colorectal cancer [J].
Osumi, Hiroki ;
Shinozaki, Eiji ;
Ooki, Akira ;
Shimozaki, Keitaro ;
Kamiimabeppu, Daisaku ;
Nakayama, Izuma ;
Wakatsuki, Takeru ;
Ogura, Mariko ;
Takahari, Daisuke ;
Chin, Keisho ;
Yamaguchi, Kensei .
CANCER MEDICINE, 2021, 10 (24) :8820-8828
[36]   Non-invasive sensitive detection of KRAS and BRAF mutation in circulating tumor cells of colorectal cancer patients [J].
Suhaimi, Nur-Afidah Mohamed ;
Foong, Yu Miin ;
Lee, Daniel Yoke San ;
Phyo, Wai Min ;
Cima, Igor ;
Lee, Esther Xing Wei ;
Goh, Wei Lin ;
Lim, Wei-Yen ;
Chia, Kee Seng ;
Kong, Say Li ;
Gong, Min ;
Lim, Bing ;
Hillmer, Axel M. ;
Koh, Poh Koon ;
Ying, Jackie Y. ;
Tan, Min-Han .
MOLECULAR ONCOLOGY, 2015, 9 (04) :850-860
[37]   Detection of circulating tumor DNA by tumor-informed whole-genome sequencing enables prediction of recurrence in stage III colorectal cancer patients [J].
Frydendahl, Amanda ;
Nors, Jesper ;
Rasmussen, Mads H. ;
Henriksen, Tenna V. ;
Nesic, Marijana ;
Reinert, Thomas ;
Afterman, Danielle ;
Lauterman, Tomer ;
Kuzman, Maja ;
Gonzalez, Santiago ;
Glavas, Dunja ;
Smadback, James ;
Maloney, Dillon ;
Levativ, Jurica ;
Yahalom, Michael ;
Ptashkin, Ryan ;
Tavassoly, Iman ;
Donenhirsh, Zohar ;
White, Eric ;
Kandasamy, Ravi ;
Alon, Ury ;
Nordentoft, Iver ;
Lindskrog, Sia V. ;
Dyrskjot, Lars ;
Jaensch, Claudia ;
Love, Uffe S. ;
Andersen, Per V. ;
Thorlacius-Ussing, Ole ;
Iversen, Lene H. ;
Gotschalck, Kare A. ;
Zviran, Asaf ;
Oklander, Boris ;
Andersen, Claus L. .
EUROPEAN JOURNAL OF CANCER, 2024, 211
[38]   Comparative analysis of mesenteric and peripheral blood circulating tumor DNA in colorectal cancer patients [J].
Taback, Bret ;
Saha, Sukamal ;
Hoon, Dave S. B. .
CIRCULATING NUCLEIC ACIDS IN PLASMA AND SERUM IV, 2006, 1075 :197-203
[39]   Circulating Tumor DNA Predicts Early Recurrence Following Locoregional Therapy for Oligometastatic Colorectal Cancer [J].
O'Donnell, Conor D. J. ;
Naleid, Nikolas ;
Siripoon, Teerada ;
Zablonski, Kevin G. ;
Storandt, Michael H. ;
Selfridge, Jennifer E. ;
Hallemeier, Christopher L. ;
Conces, Madison L. ;
Jethwa, Krishan R. ;
Bajor, David L. ;
Thiels, Cornelius A. ;
Warner, Susanne G. ;
Starlinger, Patrick P. ;
Atwell, Thomas D. ;
Mitchell, Jessica L. ;
Mahipal, Amit ;
Jin, Zhaohui .
CANCERS, 2024, 16 (13)
[40]   Evaluation a Circulating Tumor DNA in Patients with Ovarian Cancer Harboring Somatic PIK3CA or KRAS Mutations [J].
Ogasawara, Aiko ;
Hihara, Taro ;
Shintani, Daisuke ;
Yabuno, Akira ;
Ikeda, Yuji ;
Tai, Kenji ;
Fujiwara, Keiichi ;
Watanabe, Keisuke ;
Hasegawa, Kosei .
CANCER RESEARCH AND TREATMENT, 2020, 52 (04) :1219-1228