The Emergence of Drug Transporter-Mediated Multidrug Resistance to Cancer Chemotherapy

被引：202

作者：

Wu, Chung-Pu ^{[2
,3
]}

Hsieh, Chia-Hung ^{[4
]}

Wu, Yu-Shan ^{[1
]}

机构：

[1] Tunghai Univ, Dept Chem, Taichung 40704, Taiwan

[2] Chang Gung Univ, Dept Physiol & Pharmacol, Tao Yuan 333, Taiwan

[3] Chang Gung Univ, Mol Med Res Ctr, Tao Yuan 333, Taiwan

[4] China Med Univ & Hosp, Grad Inst Basic Med Sci, Taichung, Taiwan

来源：

MOLECULAR PHARMACEUTICS | 2011年 / 8卷 / 06期

关键词：

cancer; ABC transporter; multidrug resistance; tumor microenvironment; P-GLYCOPROTEIN EXPRESSION; BLOOD-BRAIN-BARRIER; HYPOXIA-INDUCIBLE FACTORS; ACUTE MYELOID-LEUKEMIA; MDR1; GENE-EXPRESSION; TYROSINE KINASE INHIBITORS; ORGANIC ANION TRANSPORTER; HUMAN LUNG-CANCER; STEM-CELLS; CROSS-RESISTANCE;

D O I：

10.1021/mp200261n

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Chemotherapy is currently one of the most effective ways to treat metastatic cancers. However, of the various mechanisms that are involved in conferring resistance, upregulation of drug efflux ATP-binding cassette (ABC) transporters, such as P-glycoprotein (ABCB1), multidrug resistance protein 1 (ABCC1) and ABCG2, has become a major obstacle to cancer chemotherapy and seriously affects the clinical outcome. To date, at least 15 ABC drug transporters have been. identified and characterized to transport and confer resistance to practically the entire spectrum of cancer drugs, causing multidrug resistance (MDR) in cancers. Unfortunately, despite decades of research, there is still no real solution to MDR. This review highlights some of the major findings, the roles and problems associated with MDR-linked ABC drug transporters in metastatic cancers and solid tumors, and the current strategies to improve the clinical outcome in cancer chemotherapy.

引用

页码：1996 / 2011

页数：16

共 246 条

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