Oxidation of retinyl acetate and analogues by nitric oxide and nitrogen dioxide

被引：8
|
作者：
Afzal, M [1 ]
Walton, JC [1 ]
机构：
[1] UNIV ST ANDREWS,SCH CHEM,ST ANDREWS KY16 9ST,FIFE,SCOTLAND
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 19期
关键词：
D O I：
10.1016/0960-894X(96)00422-2
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Nitric oxide did not react directly with retinyl acetate but, in the presence of an initiator, a series of nitroxide radicals was produced and observed by EPR spectroscopy. Product analyses showed that rapid oxidative degradation of retinyl acetate gave a series of carbonyl compounds. NO operating in concert with a self-derived initiator such as NO2 on unsaturated lipids could account for the cytotoxicity of this molecule. Copyright (C) 1996 Elsevier Science Ltd
引用
收藏
页码：2329 / 2332
页数：4
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