RETRACTED: Long non-coding RNA HULC interacts with miR-613 to regulate colon cancer growth and metastasis through targeting RTKN (Retracted Article)

被引：40
作者：
Dong, Yan [1 ]
Wei, Mao-Hua [2 ]
Lu, Jin-Gen [1 ]
Bi, Chong-Yao [3 ]
机构：
[1] Shanghai Univ Tradit Chinese Med, Inst Chinese Tradit Surg, Longhua Hosp, Shanghai 200032, Peoples R China
[2] Dalian Med Univ, Affiliated Hosp 1, Dept Gen Surg, Dalian 116011, Peoples R China
[3] Jiao Zhou Cent Hosp Qingdao, Dept Gen Surg, Qingdao 266000, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2019年 / 109卷
关键词：
Colon cancer; lncRNA; HULC; miR-613; RTKN; CELL-PROLIFERATION; GASTRIC-CANCER; MICRORNAS; LNCRNA; PROGRESSION;
D O I：
10.1016/j.biopha.2018.08.017
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Colon cancer is one of the leading causes of cancer death worldwide. Long non-coding RNA highly up-regulated in liver cancer (HULC) is an essential cancer-associated long non-coding RNA (lncRNA), contributing to the development and progression of several cancers. However, the exact effects of HULC in colon cancer progression and the underlying molecular mechanism are still unknown. In the study, we explored the detailed role of HULC in human clinical tumor tissue samples and colon cancer cell lines. The results indicated that lncRNA-HULC was markedly increased in colon cancer cell lines and accelerated colon cancer cell growth by targeting miR-613. HULC knockdown suppressed the proliferation, DNA synthesis and metastasis of human colon cancer cells in vitro. Additionally, the modulation of rhotekin (RTKN) by miR-613 was necessary in HULC-induced colon cancer cell proliferation and metastasis. The findings in the study suggested that HULC might inhibit the tumor growth through miR-613 dependent RTKN modulation. Together, our data suggested that HULC might be an oncogenic lncRNA, promoting the progression of colon cancer and could be considered as an effective therapeutic target in human colon cancer.
引用
收藏
页码：2035 / 2042
页数：8
相关论文
共 29 条
[1]   MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].
Bartel, David P. .
CELL, 2007, 131 (04) :11-29
[2]   Long non-coding RNAs and complex diseases: from experimental results to computational models [J].
Chen, Xing ;
Yan, Chenggang Clarence ;
Zhang, Xu ;
You, Zhu-Hong .
BRIEFINGS IN BIOINFORMATICS, 2017, 18 (04) :558-576
[3]   Long Noncoding RNA HULC Modulates Abnormal Lipid Metabolism in Hepatoma Cells through an miR-9-Mediated RXRA Signaling Pathway [J].
Cui, Ming ;
Xiao, Zelin ;
Wang, Yue ;
Zheng, Minying ;
Song, Tianqiang ;
Cai, Xiaoli ;
Sun, Baodi ;
Ye, Lihong ;
Zhang, Xiaodong .
CANCER RESEARCH, 2015, 75 (05) :846-857
[4]   Cancer Treatment and Survivorship Statistics, 2014 [J].
DeSantis, Carol E. ;
Lin, Chun Chieh ;
Mariotto, Angela B. ;
Siegel, Rebecca L. ;
Stein, Kevin D. ;
Kramer, Joan L. ;
Alteri, Rick ;
Robbins, Anthony S. ;
Jemal, Ahmedin .
CA-A CANCER JOURNAL FOR CLINICIANS, 2014, 64 (04) :252-271
[5]   miR-613 inhibits gastric cancer progression through repressing brain derived neurotrophic factor [J].
Ding, Dayong ;
Hou, Ruizhi ;
Gao, Yongjian ;
Feng, Ye .
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2018, 15 (02) :1735-1741
[6]   Oncomirs - microRNAs with a role in cancer [J].
Esquela-Kerscher, A ;
Slack, FJ .
NATURE REVIEWS CANCER, 2006, 6 (04) :259-269
[7]   MiR-613: a novel diagnostic and prognostic biomarker for patients with esophageal squamous cell carcinoma [J].
Guan, Shanghui ;
Wang, Cong ;
Chen, Xuan ;
Liu, Bowen ;
Tan, Bingxu ;
Liu, Fang ;
Wang, Ding ;
Han, Lihui ;
Wang, Lu ;
Huang, Xiaochen ;
Wang, Jiangfeng ;
Yao, Bin ;
Shi, Jialei ;
Chen, Pengxiang ;
Nesa, Effat Un ;
Song, Qingxu ;
Cheng, Yufeng .
TUMOR BIOLOGY, 2016, 37 (04) :4383-4391
[8]  
Hu DD, 2017, AM J CANCER RES, V7, P2070
[9]   Long noncoding RNAs POLR2E rs3787016 C/T and HULC rs7763881 A/C polymorphisms are associated with decreased risk of esophageal cancer [J].
Kang, Mingqiang ;
Sang, Yonghua ;
Gu, Haiyong ;
Zheng, Liang ;
Wang, Liming ;
Liu, Chao ;
Shi, Yijun ;
Shao, Aizhong ;
Ding, Guowen ;
Chen, Suocheng ;
Tang, Weifeng ;
Yin, Jun .
TUMOR BIOLOGY, 2015, 36 (08) :6401-6408
[10]   Let-7a inhibits tumor cell growth and metastasis by directly targeting RTKN in human colon cancer [J].
Li, Bin ;
Chen, Peng ;
Chang, Yanxiang ;
Qi, Jingpeng ;
Fu, Hui ;
Guo, Huifang .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2016, 478 (02) :739-745
123