Chromatographic resolution of anthryl- and phenanthryl-ethylamines and their use as chiral modifiers for catalytic heterogeneous hydrogenation of ethyl pyruvate

被引：0
|
作者：
Solladié-Cavallo, A
Marsol, C
Suteu, C
Garin, F
机构：
[1] Univ Strasbourg 1, ECPM, Lab Stereochim Organomet, F-67087 Strasbourg 02, France
[2] Univ Strasbourg 1, ECPM, LERCSI, F-67087 Strasbourg 02, France
[3] Chiral Technol Europe, F-67094 Illkirch Graffenstaden, France
来源：
ENANTIOMER | 2001年 / 6卷 / 04期
关键词：
aromatic-ethylamines; heterogeneous catalytic hydrogenation; chiral modifiers; chiral chromatography;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Efficient synthesis (1 to 2 steps and 95-97% overall yields) and efficient chiral chromatographic resolution of rac-anthryl-ethylamine (6a) and phenanthryl-ethylamine (7a) (35-38% of each enantiomers) have been performed. Tested as chiral modifiers for catalytic heterogeneous hydrogenation of ethyl pyruvate, (+)-6a and (+)-7a led to 12-30% ee and the monobenzyl derivative (-)-7b provided 40% ee.
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页码：245 / 249
页数：5
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