(2R*,3R*,6S*)-N,6-Bis(4-fluorophenyl)-2-(4-hydroxy-phenyl)-3,4,5,6-tetrahydro-2H-pyran-3-carboxamide

被引：8
作者：
Swamy, GYSK [1 ]
Ravikumar, K
Wadhwa, LK
Saxena, R
Singh, S
机构：
[1] Indian Inst Chem Technol, Lab Xray Crystallog, Hyderabad 500007, Andhra Pradesh, India
[2] Ind Swift Labs Ltd, Derabassi, Punjab, India
[3] Natl Inst Pharmaceut Educ & Res, SAS Nagar 160062, Punjab, India
来源：
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS | 2005年 / 61卷
关键词：
D O I：
10.1107/S1600536805031818
中图分类号：
O7 [晶体学];
学科分类号：
0702 ; 070205 ; 0703 ; 080501 ;
摘要：
The molecule of the title compound, C24H21F2NO2, has a T-shaped form in the crystal structure. The central tetrahydropyran ring shows a chair conformation. All substituents are equatorially attached to this ring. The crystal packing is stabilized by N-(HO)-O-..., O-(HO)-O-... and C-H-...pi(arene) interactions.
引用
收藏
页码：O3608 / O3610
页数：3
相关论文
共 9 条
[1]  
[Anonymous], SAINT VERS 6 28A SMA
[2]   The discovery of ezetimibe: A view from outside the receptor [J].
Clader, JW .
JOURNAL OF MEDICINAL CHEMISTRY, 2004, 47 (01) :1-9
[3]   ORTEP-3 for Windows - a version of ORTEP-III with a Graphical User Interface (GUI) [J].
Journal of Applied Crystallography, 1997, 30 (pt 5)
[4]  
Nardelli M., 1995, J APPL CRYSTALLOGR, V28, P659, DOI [10.1107/S0021889895007138, DOI 10.1107/S0021889895007138]
[5]   Ezetimibe monohydrate [J].
Ravikumar, K ;
Sridhar, B .
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2005, 61 :O2907-O2909
[6]   Discovery of 1-(4-fluorophenyl)-(3R)-[3-(4-fluorophenyl)-(3S)-hydroxypropyl]-(4S)-(4-hydroxyphenyl)-2-azetidinone (SCH 58235):: A designed, potent, orally active inhibitor of cholesterol absorption [J].
Rosenblum, SB ;
Huynh, T ;
Afonso, A ;
Davis, HR ;
Yumibe, N ;
Clader, JW ;
Burnett, DA .
JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (06) :973-980
[7]  
Sheldrick G. M., 1997, SHELXS 97 PROGRAM CR
[8]   Single-crystal structure validation with the program PLATON [J].
Spek, AL .
JOURNAL OF APPLIED CRYSTALLOGRAPHY, 2003, 36 :7-13
[9]   Inhibition of intestinal cholesterol absorption by ezetimibe in humans [J].
Sudhop, T ;
Lütjohann, D ;
Kodal, A ;
Igel, M ;
Tribble, DL ;
Shah, S ;
Perevozskaya, I ;
von Bergmann, K .
CIRCULATION, 2002, 106 (15) :1943-1948
1