The role of microRNAs in self-renewal and differentiation of mesenchymal stem cells

被引：131

作者：

Guo, Ling ^{[3
]}

Zhao, Robert C. H. ^{[1
,2
]}

Wu, Yaojiong ^{[3
]}

机构：

[1] Chinese Acad Med Sci, Inst Basic Med Sci, Ctr Excellence Tissue Engn, Dept Cell Biol, Beijing 100730, Peoples R China

[2] Peking Union Med Coll, Sch Basic Med, Beijing 100021, Peoples R China

[3] Tsinghua Univ, Div Life Sci, Grad Sch Shenzhen, Shenzhen 518057, Peoples R China

来源：

EXPERIMENTAL HEMATOLOGY | 2011年 / 39卷 / 06期

基金：

中国国家自然科学基金;

关键词：

HUMAN ADIPOSE-TISSUE; MUSCLE-SPECIFIC MICRORNA; MARROW STROMAL CELLS; BONE-MARROW; OSTEOBLAST DIFFERENTIATION; OSTEOGENIC DIFFERENTIATION; PROGENITOR CELLS; EXPRESSION; PLURIPOTENCY; MECHANISM;

D O I：

10.1016/j.exphem.2011.01.011

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

MicroRNAs (miRNAs) are short non-coding RNAs involved in post-trascriptional regulation of gene expression and diverse biological activities. They are crucial for self-renewal and behavior of embryonic stem cells, but their role in mesenchymal stem cells has been poorly understood. Recently emerging evidence suggests that miRNAs are closely involved in controlling key steps of mesenchymal stem cell differentiation into certain cell lineages. This review focuses on miRNAs identified recently that regulate mesenchymal stem cell differentiation and other activities. (C) 2011 ISEH - Society for Hematology and Stem Cells. Published by Elsevier Inc.

引用

页码：608 / 616

页数：9

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