Synthesis of N-methoxy-1 phosphoryloxy imidates through a copper-catalyzed cross-dehydrogenative coupling of N-methoxylamides with phosphites

被引：6

作者：

Deng, Xiangmeng ^{[1
]}

Wang, Ying ^{[1
]}

Liu, Jin-Biao ^{[1
]}

Wan, Changfeng ^{[2
]}

Luo, Nianhua ^{[3
]}

机构：

[1] Jiangxi Univ Sci & Technol, Jiangxi Prov Key Lab Funct Mol Mat Chem, Ganzhou 341000, Peoples R China

[2] Jiangxi Normal Univ, Coll Chem & Chem Engn, Nanchang 330022, Peoples R China

[3] Gannan Med Univ, Sch Pharmaceut Sci, Ganzhou 341000, Peoples R China

来源：

TETRAHEDRON LETTERS | 2022年 / 105卷

基金：

中国国家自然科学基金;

关键词：

Copper catalysis; N-methoxylamide; Phosphite; Cross-dehydrogenative coupling; P-O; H-PHOSPHONATES; GENERAL-METHOD; ALCOHOLS; OXIDES; EFFICIENT; PROTOCOL; AMINES; ESTERS; AMIDES;

D O I：

10.1016/j.tetlet.2022.154049

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Phosphonates are important organic compounds, which are widely used in medicine, materials, agricul-ture and catalysis. In this paper, we report a copper-catalyzed cross-dehydrogenative coupling of N- methoxamides with various phosphites to synthesize a series of N-methoxy-1 phosphoryloxy imidates. O-Functionalization of N-methoxamides has been achieved, and N-functionalization was avoided by employing this methodology. Studies show that the N-methoxy group is essential for the selectivity and activity of the reaction. (c) 2022 Elsevier Ltd. All rights reserved.

引用

页数：5

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