Common genetic variation near MC4R is associated with waist circumference and insulin resistance

被引：362
作者：
Chambers, John C. [2 ]
Elliott, Paul [2 ]
Zabaneh, Delilah [2 ]
Zhang, Weihua [2 ]
Li, Yun [3 ]
Froguel, Philippe [4 ]
Balding, David [2 ]
Scott, James [1 ]
Kooner, Jaspal S. [1 ]
机构：
[1] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Natl Heart & Lung Inst, London W12 0NN, England
[2] Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Publ Hlth, London W2 1PG, England
[3] Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA
[4] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Sect Genom Med, London W12 0NN, England
来源：
NATURE GENETICS | 2008年 / 40卷 / 06期
基金：
英国医学研究理事会; 英国惠康基金;
关键词：
D O I：
10.1038/ng.156
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
We carried out a genome-wide association study (318,237 SNPs) for insulin resistance and related phenotypes in 2,684 Indian Asians, with further testing in 11,955 individuals of Indian Asian or European ancestry. We found associations of rs12970134 near MC4R with waist circumference (P = 1.7 x 10(-9)) and, independently, with insulin resistance. Homozygotes for the risk allele of rs12970134 have similar to 2 cm increased waist circumference. Common genetic variation near MC4R is associated with risk of adiposity and insulin resistance.
引用
收藏
页码：716 / 718
页数：3
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