Keeping the Soma Free of Transposons: Programmed DNA Elimination in Ciliates

被引：29

作者：

Schoeberl, Ursula E. ^{[1
]}

Mochizuki, Kazufumi ^{[1
]}

机构：

[1] Austrian Acad Sci IMBA, Inst Mol Biotechnol, A-1030 Vienna, Austria

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2011年 / 286卷 / 43期

基金：

奥地利科学基金会; 欧洲研究理事会;

关键词：

DICER-LIKE PROTEIN; TETRAHYMENA-THERMOPHILA; GENOME REARRANGEMENTS; SMALL RNAS; MACRONUCLEAR DEVELOPMENT; CHROMODOMAIN PROTEIN; MEIOTIC PROPHASE; DELETION ELEMENT; SEQUENCE; METHYLATION;

D O I：

10.1074/jbc.R111.276964

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Many transposon-related sequences are removed from the somatic macronucleus of ciliates during sexual reproduction. In the ciliate Tetrahymena, an RNAi-related mechanism produces small noncoding RNAs that induce heterochromatin formation, which is followed by DNA elimination. Because RNAi-related mechanisms repress transposon activities in a variety of eukaryotes, the DNA elimination mechanism of ciliates might have evolved from these types of transposon-silencing mechanisms. Nuclear dimorphism allows ciliates to identify any DNA that has invaded the germ-line micronucleus using small RNAs and a whole genome comparison of the micronucleus and the somatic macronucleus.

引用

页码：37045 / 37052

页数：8

共 68 条

[61] Phosphorylation of linker histone is associated with transcriptional activation in a normally silent nucleus [J].

Sweet, MT ;

Jones, K ;

Allis, CD .

JOURNAL OF CELL BIOLOGY, 1996, 135 (05) :1219-1228

[62] Methylation of histone H3 at lysine 9 targets programmed DNA elimination in Tetrahymena [J].

Taverna, SD ;

Coyne, RS ;

Allis, CD .

CELL, 2002, 110 (06) :701-711

[63] Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes [J].

Wang, Yanli ;

Juranek, Stefan ;

Li, Haitao ;

Sheng, Gang ;

Wardle, Greg S. ;

Tuschl, Thomas ;

Patel, Dinshaw J. .

NATURE, 2009, 461 (7265) :754-U3

[64] A novel family of mobile genetic elements is limited to the germline genome in Tetrahymena thermophila [J].

Wuitschick, JD ;

Gershan, JA ;

Lochowicz, AJ ;

Li, SQ ;

Karrer, KM .

NUCLEIC ACIDS RESEARCH, 2002, 30 (11) :2524-2537

[65] Programmed DNA deletion as an RNA-guided system of genome defense [J].

Yao, MC ;

Fuller, P ;

Xi, XH .

SCIENCE, 2003, 300 (5625) :1581-1584

[66] DNA ELIMINATION IN TETRAHYMENA - A DEVELOPMENTAL PROCESS INVOLVING EXTENSIVE BREAKAGE AND REJOINING OF DNA AT DEFINED SITES [J].

YAO, MC ;

CHOI, J ;

YOKOYAMA, S ;

AUSTERBERRY, CF ;

YAO, CH .

CELL, 1984, 36 (02) :433-440

[67] Identification of novel chromatin-associated proteins involved in programmed genome rearrangements in Tetrahymena [J].

Yao, Meng-Chao ;

Yao, Ching-Ho ;

Halasz, Lia M. ;

Fuller, Patrick ;

Rexer, Charles H. ;

Wang, Sidney H. ;

Jain, Rajat ;

Coyne, Robert S. ;

Chalker, Douglas L. .

JOURNAL OF CELL SCIENCE, 2007, 120 (12) :1978-1989

[68] Methylation as a crucial step in plant microRNA biogenesis [J].

Yu, B ;

Yang, ZY ;

Li, JJ ;

Minakhina, S ;

Yang, MC ;

Padgett, RW ;

Steward, R ;

Chen, XM .

SCIENCE, 2005, 307 (5711) :932-935

← 1 2 3 4 5 6 7 →