Keeping the Soma Free of Transposons: Programmed DNA Elimination in Ciliates

被引：29

作者：

Schoeberl, Ursula E. ^{[1
]}

Mochizuki, Kazufumi ^{[1
]}

机构：

[1] Austrian Acad Sci IMBA, Inst Mol Biotechnol, A-1030 Vienna, Austria

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2011年 / 286卷 / 43期

基金：

奥地利科学基金会; 欧洲研究理事会;

关键词：

DICER-LIKE PROTEIN; TETRAHYMENA-THERMOPHILA; GENOME REARRANGEMENTS; SMALL RNAS; MACRONUCLEAR DEVELOPMENT; CHROMODOMAIN PROTEIN; MEIOTIC PROPHASE; DELETION ELEMENT; SEQUENCE; METHYLATION;

D O I：

10.1074/jbc.R111.276964

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Many transposon-related sequences are removed from the somatic macronucleus of ciliates during sexual reproduction. In the ciliate Tetrahymena, an RNAi-related mechanism produces small noncoding RNAs that induce heterochromatin formation, which is followed by DNA elimination. Because RNAi-related mechanisms repress transposon activities in a variety of eukaryotes, the DNA elimination mechanism of ciliates might have evolved from these types of transposon-silencing mechanisms. Nuclear dimorphism allows ciliates to identify any DNA that has invaded the germ-line micronucleus using small RNAs and a whole genome comparison of the micronucleus and the somatic macronucleus.

引用

页码：37045 / 37052

页数：8

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