The Physiology, Pathology, and Potential Therapeutic Applications of the TREM2 Signaling Pathway

被引：355
作者：
Deczkowska, Aleksandra [1 ]
Weiner, Assaf [1 ]
Amit, Ido [1 ]
机构：
[1] Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel
来源：
CELL | 2020年 / 181卷 / 06期
基金：
以色列科学基金会; 欧洲研究理事会;
关键词：
FLUID SOLUBLE TREM2; MYELOID CELLS 2; ALZHEIMERS-DISEASE; CEREBROSPINAL-FLUID; INFLAMMATORY RESPONSES; CUTTING EDGE; AMYLOID-BETA; MICROGLIA; RECEPTOR; MOUSE;
D O I：
10.1016/j.cell.2020.05.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Alzheimer's disease, obesity-related metabolic syndrome, and cancer are the leading causes of death and among the most costly medical conditions in the Western world. In all three cases, recent discoveries establish the TREM2 receptor as a major pathology-induced immune signaling hub that senses tissue damage and activates robust immune remodeling in response to it. In this review, we summarize and question what is known and remains to be discovered about TREM2 signaling pathway, track the consequences of its activation in physiological niches and pathological contexts, and highlight the promising potential of therapeutic manipulation of TREM2 signaling.
引用
收藏
页码：1207 / 1217
页数：11
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