New light on polyglutamine neurodegenerative disorders:: interference with transcription

被引：15

作者：

Néri, C ^{[1
]}

机构：

[1] CEPH, Fdn Jean Dausset, Lab Genom Biol, F-75010 Paris, France

来源：

TRENDS IN MOLECULAR MEDICINE | 2001年 / 7卷 / 07期

关键词：

D O I：

10.1016/S1471-4914(01)02065-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

There is accumulating evidence that aberrant transcriptional regulation is involved in neurodegenerative disorders associated with expanded polyglutamines, Recent work on the coactivator CREB-binding protein suggests that transcription factors containing a normal polyglutamine stretch might be redistributed to nuclear inclusions and cytoplasmic aggregates, resulting in cellular toxicity.

引用

页码：283 / 284

页数：2

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