New light on polyglutamine neurodegenerative disorders:: interference with transcription

被引：15
|
作者：
Néri, C [1 ]
机构：
[1] CEPH, Fdn Jean Dausset, Lab Genom Biol, F-75010 Paris, France
来源：
TRENDS IN MOLECULAR MEDICINE | 2001年 / 7卷 / 07期
关键词：
D O I：
10.1016/S1471-4914(01)02065-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
There is accumulating evidence that aberrant transcriptional regulation is involved in neurodegenerative disorders associated with expanded polyglutamines, Recent work on the coactivator CREB-binding protein suggests that transcription factors containing a normal polyglutamine stretch might be redistributed to nuclear inclusions and cytoplasmic aggregates, resulting in cellular toxicity.
引用
收藏
页码：283 / 284
页数：2
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