Death by a thousand cuts: Granzyme pathways of programmed cell death

被引：494

作者：

Chowdhury, Dipanjan ^{[1
,2
]}

Lieberman, Judy ^{[3
,4
]}

机构：

[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Radiat Oncol, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Immune Dis Inst, Boston, MA 02115 USA

[4] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA

来源：

ANNUAL REVIEW OF IMMUNOLOGY | 2008年 / 26卷

关键词：

cytotoxic T lymphocyte; cytotoxic granule; natural killer cell; serine protease; granule exocytosis; serpin;

D O I：

10.1146/annurev.immunol.26.021607.090404

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The granzymes ire cell death-inducing enzymes, stored in the cytotoxic granules of cytotoxic T lymphocytes and natural killer cells, that are released during granule exocytosis when a specific virus-infected or transformed target cell is marked for elimination. Recent work suggests that this homologous family of serine esterases can activate at least three distinct pathways of cell death. This redundancy likely evolved to provide protection against pathogens and tumors with diverse strategies for evading cell death. This review discusses what is known about granzyme-mediated pathways of cell death as well as recent studies that implicate granzymes in immune regulation and extracellular proteolytic functions in inflammation.

引用

页码：389 / 420

页数：32

共 208 条

[1] Molecular ordering of the caspase activation cascade initiated by the cytotoxic T lymphocyte/natural killer (CTL/NK) protease granzyme B [J].

Adrain, C ;

Murphy, BM ;

Martin, SJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (06) :4663-4673

[2] A novel domain in adenovirus L4-100K is required for stable binding and efficient inhibition of human granzyme B: Possible interaction with a species-specific exosite [J].

Andrade, F ;

Casciola-Rosen, LA ;

Rosen, A .

MOLECULAR AND CELLULAR BIOLOGY, 2003, 23 (17) :6315-6326

[3] Adenovirus L4-100K assembly protein is a granzyme B substrate that potently inhibits granzyme B-mediated cell death [J].

Andrade, F ;

Bull, HG ;

Thornberry, NA ;

Ketner, GW ;

Casciola-Rosen, LA ;

Rosen, A .

IMMUNITY, 2001, 14 (06) :751-761

[4] Granzyme H destroys the function of critical adenoviral proteins required for viral DNA replication and granzyme B inhibition [J].

Andrade, Felipe ;

Fellows, Edward ;

Jenne, Dieter E. ;

Rosen, Antony ;

Young, C. S. H. .

EMBO JOURNAL, 2007, 26 (08) :2148-2157

[5] In vivo regulation of murine granzyme B gene transcription in activated primary T cells [J].

Babichuk, CK ;

Duggan, BL ;

Bleackley, RC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (28) :16485-16493

[6] Mutational analysis of the murine granzyme B gene promoter in primary T cells and a T cell clone [J].

Babichuk, CK ;

Bleackley, RC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (30) :18564-18571

[7] Detection of soluble human granzyme K in vitro and in vivo [J].

Bade, B ;

Lohrmann, J ;

ten Brinke, A ;

Wolbink, AM ;

Wolbink, GJ ;

ten Berge, IJM ;

Virchow, JC ;

Luttmann, W ;

Hack, CE .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2005, 35 (10) :2940-2948

[8] Surface cathepsin B protects cytotoxic lymphocytes from self-destruction after degranulation [J].

Balaji, KN ;

Schaschke, N ;

Machleidt, W ;

Catalfamo, M ;

Henkart, PA .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 196 (04) :493-503

[9] Cytotoxic T lymphocytes from cathepsin B-deficient mice survive normally in vitro and in vivo after encountering and killing target cells [J].

Baran, Katherine ;

Ciccone, Annette ;

Peters, Christoph ;

Yagita, Hideo ;

Bird, Phillip I. ;

Villadangos, Jose A. ;

Trapani, Joseph A. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (41) :30485-30491

[10] Antiviral cytokines induce hepatic expression of the granzyme B inhibitors, proteinase inhibitor 9 and serine proteinase inhibitor 6 [J].

Barrie, MB ;

Stout, HW ;

Abougergi, MS ;

Miller, BC ;

Thiele, DL .

JOURNAL OF IMMUNOLOGY, 2004, 172 (10) :6453-6459

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