Mass spectrometric studies of the variety of beta-amyloid proteoforms in Alzheimer's disease

被引:11
作者
Zakharova, Natalia V. [1 ]
Kononikhin, Alexey S. [2 ,3 ]
Indeykina, Maria I. [1 ,3 ]
Bugrova, Anna E. [1 ,2 ]
Strelnikova, Polina [1 ,4 ]
Pekov, Stanislav [2 ,3 ,4 ]
Kozin, Sergey A. [3 ]
Popov, Igor A. [4 ,5 ]
Mitkevich, Vladimir [3 ]
Makarov, Alexander A. [3 ]
Nikolaev, Evgeny N. [2 ]
机构
[1] Russian Acad Sci, Emanuel Inst Biochem Phys, Moscow, Russia
[2] Skolkovo Inst Sci & Technol, CMCB, Moscow, Russia
[3] Russian Acad Sci, Engelhardt Inst Mol Biol, Moscow, Russia
[4] Moscow Inst Phys & Technol, Lab Ion & Mol Phys, Dolgoprudnyi, Russia
[5] Russian Acad Sci, VL Talrose Inst Energy Problems Chem Phys, NN Semenov Fed Ctr Chem Phys, Moscow, Russia
关键词
Alzheimer's disease (AD); A beta peptides; beta-amyloid; IMS; isoforms; LC-MS; MALDI-TOF; mass spectrometry (MS); post-translational modifications (PTMs); proteoforms; CENTRAL-NERVOUS-SYSTEM; TARGETING A-BETA; CEREBROSPINAL-FLUID; ISOASPARTATE FORMATION; RELATIVE QUANTITATION; BETA-ASP7; ISOFORMS; PRECURSOR PROTEIN; CLINICAL-TRIALS; SER(26) RESIDUE; ACID-RESIDUES;
D O I
10.1002/mas.21775
中图分类号
O433 [光谱学];
学科分类号
0703 ; 070302 ;
摘要
This review covers the results of the application of mass spectrometric (MS) techniques to study the diversity of beta-amyloid (A beta) peptides in human samples. Since A beta is an important hallmark of Alzheimer's disease (AD), which is a socially significant neurodegenerative disorder of the elderly worldwide, analysis of its endogenous variations is of particular importance for elucidating the pathogenesis of AD, predicting increased risks of the disease onset, and developing effective therapy. MS approaches have no alternative for the study of complex samples, including a wide variety of A beta proteoforms, differing in length and modifications. Approaches based on matrix-assisted laser desorption/ionization time-of-flight and liquid chromatography with electrospray ionization tandem MS are most common in A beta studies. However, A beta forms with isomerized and/or racemized Asp and Ser residues require the use of special methods for separation and extra sensitive and selective methods for detection. Overall, this review summarizes current knowledge of A beta species found in human brain, cerebrospinal fluid, and blood plasma; focuses on application of different MS approaches for A beta studies; and considers the potential of MS techniques for further studies of A beta-peptides.
引用
收藏
页码:3 / 21
页数:19
相关论文
共 140 条
[1]   Distinguishing and quantifying peptides and proteins containing D-amino acids by tandem mass spectrometry [J].
Adams, CM ;
Zubarev, RA .
ANALYTICAL CHEMISTRY, 2005, 77 (14) :4571-4580
[2]   Metals and Alzheimer's Disease: How Far Have We Come in the Clinic? [J].
Adlard, Paul A. ;
Bush, Ashley I. .
JOURNAL OF ALZHEIMERS DISEASE, 2018, 62 (03) :1369-1379
[3]   Mass spectrometry-based proteomics [J].
Aebersold, R ;
Mann, M .
NATURE, 2003, 422 (6928) :198-207
[4]  
Alzheimer's Association, 2016, Alzheimers Dement, V12, P459
[5]   Detection and Identification of Bioanalytes with High Resolution LSPR Spectroscopy and MALDI Mass Spectrometry [J].
Anker, Jeffrey N. ;
Hall, W. Paige ;
Lambert, Mary P. ;
Velasco, Pauline T. ;
Mrksich, Milan ;
Klein, William L. ;
Van Duyne, Richard P. .
JOURNAL OF PHYSICAL CHEMISTRY C, 2009, 113 (15) :5891-5894
[6]   Epitomic Characterization of the Specificity of the Anti-Amyloid Aβ Monoclonal Antibodies 6E10 and 4G8 [J].
Baghallab, Ibtisam ;
Reyes-Ruiz, Jorge Mauricio ;
Abulnaja, Khalid ;
Huwait, Etimad ;
Glabe, Charles .
JOURNAL OF ALZHEIMERS DISEASE, 2018, 66 (03) :1235-1244
[7]   Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease [J].
Bard, F ;
Cannon, C ;
Barbour, R ;
Burke, RL ;
Games, D ;
Grajeda, H ;
Guido, T ;
Hu, K ;
Huang, JP ;
Johnson-Wood, K ;
Khan, K ;
Kholodenko, D ;
Lee, M ;
Lieberburg, I ;
Motter, R ;
Nguyen, M ;
Soriano, F ;
Vasquez, N ;
Weiss, K ;
Welch, B ;
Seubert, P ;
Schenk, D ;
Yednock, T .
NATURE MEDICINE, 2000, 6 (08) :916-919
[8]   Phosphorylation of the Amyloid-Beta Peptide Inhibits Zinc-Dependent Aggregation, Prevents Na,K-ATPase Inhibition, and Reduces Cerebral Plaque Deposition [J].
Barykin, Evgeny P. ;
Petrushanko, Irina Y. ;
Kozin, Sergey A. ;
Telegin, Georgy B. ;
Chernov, Alexander S. ;
Lopina, Olga D. ;
Radko, Sergey P. ;
Mitkevich, Vladimir A. ;
Makarov, Alexander A. .
FRONTIERS IN MOLECULAR NEUROSCIENCE, 2018, 11
[9]   Dual strategy for reduced signal-suppression effects in matrix-assisted laser desorption/ionization mass spectrometry imaging [J].
Bastrup, Joakim ;
Birkelund, Svend ;
Asuni, Ayodeji A. ;
Volbracht, Christiane ;
Stensballe, Allan .
RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2019, 33 (22) :1711-1721
[10]   An online nano-LC-ESI-FTICR-MS method for comprehensive characterization of endogenous fragments from amyloid β and amyloid precursor protein in human and cat cerebrospinal fluid [J].
Brinkmalm, Gunnar ;
Portelius, Erik ;
Ohrfelt, Annika ;
Mattsson, Niklas ;
Persson, Rita ;
Gustavsson, Mikael K. ;
Vite, Charles H. ;
Gobom, Johan ;
Mansson, Jan-Eric ;
Nilsson, Jonas ;
Halim, Adnan ;
Larson, Goran ;
Ruetschi, Ulla ;
Zetterberg, Henrik ;
Blennow, Kaj ;
Brinkmalm, Ann .
JOURNAL OF MASS SPECTROMETRY, 2012, 47 (05) :591-603