Effects of Oxysterols on Immune Cells and Related Diseases

被引：29
作者：
de Freitas, Fabio Alessandro [1 ]
Levy, Debora [1 ]
Reichert, Cadiele Oliana [1 ]
Cunha-Neto, Edecio [2 ,3 ]
Kalil, Jorge [3 ,4 ]
Bydlowski, Sergio Paulo [1 ,5 ]
机构：
[1] Univ Sao Paulo, Lipids Oxidat & Cell Biol Team, Lab Immunol LIM19, Heart Inst InCor,Fac Med, BR-05403900 Sao Paulo, SP, Brazil
[2] Univ Sao Paulo, Lab Clin Immunol & Allergy LIM60, Heart Inst InCor, Fac Med, BR-05403900 Sao Paulo, SP, Brazil
[3] Natl Inst Sci & Technol Invest Immunol IIII INCT, BR-05403000 Sao Paulo, SP, Brazil
[4] Univ Sao Paulo, Fac Med, Lab Immunol LIM19, Heart Inst InCor, BR-05403900 Sao Paulo, SP, Brazil
[5] Natl Inst Sci & Technol Regenerat Med INCT Regene, CNPq, BR-21941902 Rio De Janeiro, RJ, Brazil
来源：
CELLS | 2022年 / 11卷 / 08期
基金：
巴西圣保罗研究基金会;
关键词：
oxysterols; 25-hydroxycholesterol; 7; alpha; 25-dihydroxycholesterol; immune cells; immune diseases; EBI2; LXR; MULTIPLE-SCLEROSIS; OXIDATION-PRODUCTS; CHOLESTEROL; 24-HYDROXYLASE; NEUROMUSCULAR-TRANSMISSION; 7-TRANSMEMBRANE RECEPTOR; SIGNALING PATHWAY; GENE-EXPRESSION; DENDRITIC CELLS; PLASMA-LEVELS; EBI2;
D O I：
10.3390/cells11081251
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Oxysterols are the products of cholesterol oxidation. They have a wide range of effects on several cells, organs, and systems in the body. Oxysterols also have an influence on the physiology of the immune system, from immune cell maturation and migration to innate and humoral immune responses. In this regard, oxysterols have been involved in several diseases that have an immune component, from autoimmune and neurodegenerative diseases to inflammatory diseases, atherosclerosis, and cancer. Here, we review data on the participation of oxysterols, mainly 25-hydroxycholesterol and 7 alpha,25-dihydroxycholesterol, in the immune system and related diseases. The effects of these oxysterols and main oxysterol receptors, LXR and EBI2, in cells of the immune system (B cells, T cells, macrophages, dendritic cells, oligodendrocytes, and astrocytes), and in immune-related diseases, such as neurodegenerative diseases, intestinal diseases, cancer, respiratory diseases, and atherosclerosis, are discussed.
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页数：26
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