13q14 Deletion Size and Number of Deleted Cells Both Influence Prognosis in Chronic Lymphocytic Leukemia

被引：64

作者：

Dal Bo, Michele ^{[1
]}

Rossi, Francesca Maria ^{[1
]}

Rossi, Davide ^{[2
,3
]}

Deambrogi, Clara ^{[2
,3
]}

Bertoni, Francesco ^{[4
,5
]}

Del Giudice, Ilaria ^{[6
]}

Palumbo, Giuseppe ^{[7
]}

Nanni, Mauro ^{[6
]}

Rinaldi, Andrea ^{[4
,5
]}

Kwee, Ivo ^{[4
,5
,8
]}

Tissino, Erika ^{[1
]}

Corradini, Giorgia ^{[9
]}

Gozzetti, Alessandro ^{[10
]}

Cencini, Emanuele ^{[10
]}

Ladetto, Marco ^{[11
]}

Coletta, Angela Maria ^{[12
,13
]}

Luciano, Fabrizio ^{[12
,13
]}

Bulian, Pietro ^{[1
]}

Pozzato, Gabriele ^{[14
]}

Laurenti, Luca ^{[15
]}

Forconi, Francesco ^{[10
]}

Di Raimondo, Francesco ^{[7
]}

Marasca, Roberto ^{[9
]}

Del Poeta, Giovanni ^{[12
,13
]}

Gaidano, Gianluca ^{[2
,3
]}

Foa, Robin ^{[6
]}

Guarini, Anna ^{[6
]}

Gattei, Valter ^{[1
]}

机构：

[1] IRCCS, Ctr Riferimento Oncol, Clin & Expt Oncohematol Unit, Aviano, PN, Italy

[2] Amedeo Avogadro Univ Eastern Piedmont, Dept Clin & Expt Med, Div Hematol, Novara, Italy

[3] Amedeo Avogadro Univ Eastern Piedmont, IRCAD, Novara, Italy

[4] Oncol Inst So Switzerland IOSI, Expt Oncol Lab, Bellinzona, Switzerland

[5] Oncol Inst So Switzerland IOSI, Lymphoma Unit, Bellinzona, Switzerland

[6] Univ Roma La Sapienza, Dept Cellular Biotechnol & Hematol, Div Hematol, Rome, Italy

[7] Ferrarotto Hosp, Div Hematol, Catania, Italy

[8] Ist Dalle Molle Studi Intelligenza Artificiale ID, Manno, Switzerland

[9] Univ Modena & Reggio Emilia, Dept Hematol & Oncol, Div Hematol, Modena, Italy

[10] Univ Siena, Div Hematol & Transplant, Dept Clin Med & Immunol Sci, I-53100 Siena, Italy

[11] Univ Turin, Dept Expt Med & Oncol, Div Hematol, I-10124 Turin, Italy

[12] S Eugenio Hosp, Div Hematol, Rome, Italy

[13] Univ Roma Tor Vergata, Rome, Italy

[14] Univ Trieste, Maggiore Gen Hosp, Dept Internal Med & Hematol, Trieste, Italy

[15] Univ Cattolica Sacro Cuore, Inst Hematol, Rome, Italy

来源：

GENES CHROMOSOMES & CANCER | 2011年 / 50卷 / 08期

关键词：

TUMOR-SUPPRESSOR GENE; MUTATION STATUS; GENOMIC ABERRATIONS; PROTEIN EXPRESSION; ZAP-70; EXPRESSION; CYCLE PROGRESSION; CHROMOSOME; 13Q14; CD38; DOWN-REGULATION; REGION;

D O I：

10.1002/gcc.20885

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Deletion at 13q14 is detected by fluorescence in situ hybridization (FISH) in about 50% of chronic lymphocytic leukemia (CLL). Although CLL with 13q deletion as the sole cytogenetic abnormality (del13q-only) usually have good prognosis, more aggressive clinical courses are documented for del13q-only CLL carrying higher percentages of 13q deleted nuclei. Moreover, deletion at 13q of different sizes have been described, whose prognostic significance is still unknown. In a multi-institutional cohort of 342 del13q-only cases and in a consecutive unselected cohort of 265 CLL, we investigated the prognostic significance of 13q deletion, using the 13q FISH probes locus-specific identifier (LSI)-D13S319 and LSI-RB1 that detect the DLEU2/MIR15A/MIR16-1 and RB1 loci, respectively. Results indicated that both percentage of deleted nuclei and presence of larger deletions involving the RB1 locus cooperated to refine the prognosis of del13q-only cases. In particular, CLL carrying < 70% of 13q deleted nuclei with deletions not comprising the RB1 locus were characterized by particularly long time-to-treatment. Conversely, CLL with 13q deletion in < 70% of nuclei but involving the RB1 locus, or CLL carrying 13q deletion in >= 70% of nuclei, with or without RB1 deletions, collectively experienced shorter time-to-treatment. A revised flowchart for the prognostic FISH assessment of del13q-only CLL, implying the usage of both 13q probes, is proposed. (C) 2011 Wiley-Liss, Inc.

引用

页码：633 / 643

页数：11

共 31 条

[31] Detection of t(12;14)(p13;q32) in a patient with IGH-CCND1 negative mantle cell lymphoma resembling ultra-high risk chronic lymphocytic leukemia
Miao, Yi
Wang, Rong
Fan, Lei
Qiu, Hairong
Wu, Yujie
Chen, Yaoyu
Xu, Wei
Li, Jianyong
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2015, 8 (06): : 7494 - 7498

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