Microwave-mediated synthesis of a cyclic heptapeptoid through consecutive Ugi reactions

被引：9

作者：

Barreto, Angelica de Fatima S. ^{[1
]}

Andrade, Carlos Kleber Z. ^{[1
]}

机构：

[1] Univ Brasilia, Inst Quim, Lab Quim Metodol & Organ Sintet, BR-70910970 Brasilia, DF, Brazil

来源：

TETRAHEDRON | 2018年 / 74卷 / 48期

关键词：

Cyclic peptoids; Consecutive Ugi reactions; Isocyanide-based multicomponent reactions (IMCRs); Microwave-mediated reactions; Macroheterocycles; MULTICOMPONENT REACTIONS; NATURAL-PRODUCTS; PEPTOIDS; SOLVENT; PEPTIDE; CHEMISTRY;

D O I：

10.1016/j.tet.2018.10.018

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The combination of consecutive Isocyanide-based Multicomponent Reactions (IMCRs) allowed the synthesis of a cyclic heptapeptoid in a reduced number of steps. Herein, we describe this efficient approach using four consecutive Ugi reactions, being three Ugi four-center, four-component reactions, and one Ugi four-center, three-component reaction. Our strategy involved eight steps of which seven in a row were microwave-assisted with reaction times of 3-5 min and yields ranging from 88 to 98%. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：6861 / 6865

页数：5

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