A Lesion Microenvironment-Responsive Fungicide Nanoplatform for Crop Disease Prevention and Control

被引：13

作者：

Wang, Chao-Yi ^{[1
,2
]}

Jia, Chengguo ^{[1
]}

Zhang, Ming-Zhe ^{[1
]}

Yang, Song ^{[1
]}

Qin, Jian-Chun ^{[1
]}

Yang, Ying-Wei ^{[2
]}

机构：

[1] Jilin Univ, Coll Plant Sci, Changchun 130012, Peoples R China

[2] Jilin Univ, Coll Chem, Changchun 130012, Peoples R China

来源：

ADVANCED HEALTHCARE MATERIALS | 2022年 / 11卷 / 10期

基金：

中国国家自然科学基金;

关键词：

drug delivery systems; functional nanosystems; smart materials; stimuli-responsiveness; supramolecular materials; MESOPOROUS SILICA NANOPARTICLES; SURFACE MODIFICATION; IN-VITRO; EUGENOL; DRUG; POLYDOPAMINE; RESISTANCE; TOMATO; SYSTEM;

D O I：

10.1002/adhm.202102617

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Controlled fungicide delivery in response to the specific microenvironment produced by fungal pathogens is an advisable strategy to improve the efficacy of fungicides. Herein, the authors construct a smart fungicide nanoplatform, using mesoporous silica nanoparticles (MSNs) as nanocarriers loaded with eugenol (EU) and Ag+ coordinated polydopamine (Ag+-PDA) as a coating to form Ag+-PDA@MSNs-EU NPs for Botrytis cinerea (B. cinerea) control. As a botanical fungicide, EU offers an eco-friendly alternative to synthetic fungicides and can upregulate several defense-related genes in the tomato plant. The Ag+-PDA coating can lock the EU inside the nanocarriers and respond to the oxalic acid produced by B. cinerea to corelease the loaded EU and Ag+. The results demonstrate that Ag+-PDA@MSNs-EU NPs can effectively inhibit the mycelial growth of B. cinerea on detached and potted tomato leaves. The construction of such a smart fungicide nanoplatform provides new guidance to design controlled fungicides release systems, which can respond to the microenvironment associated with plant pathogen to realize fungus control.

引用

页数：13