Citalopram plus reboxetine in treatment-resistant obsessive-compulsive disorder

被引:7
作者
Fontenelle, LF
Mendlowicz, MV
Miguel, EC
Versiani, M
机构
[1] IPUB UFRJ, Inst Psychiat, Anxiety & Depress Res Program, Rio De Janeiro, Brazil
[2] IPUB UFRJ, Inst Psychiat, Ethics & Forens Psychiat Res Program, Rio De Janeiro, Brazil
[3] UFF, MSM, Dept Psychiat & Mental Hlth, Niteroi, RJ, Brazil
[4] USP, Sch Med, Obsess Compuls Spectrum Disorders Clin PROTOG, Dept Psychiat, BR-09500900 Sao Paulo, Brazil
关键词
obsessive-compulsive disorder; citalopram; reboxetine;
D O I
10.1080/15622970510029740
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
While serotonin reuptake inhibitors (SRIs) are the first-line treatment of obsessive-compulsive disorder (OCD), as many as 40-60% of patients fail to respond to adequate trials with these drugs. In this study, we describe the case of a patient with an SRI-resistant OCD who was successfully treated with a combination of citalopram (a selective SRI) and reboxetine (a selective noradrenaline reuptake inhibitor (SNRI)). This report suggests that future studies accessing the efficacy of the SRI-SNRI combination in treatment resistant OCD are needed.
引用
收藏
页码:57 / 59
页数:3
相关论文
共 22 条
[1]   Multivariate meta-analysis of controlled drug studies for obsessive-compulsive disorder [J].
Ackerman, DL ;
Greenland, S .
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 2002, 22 (03) :309-317
[2]   Venlafaxine versus clomipramine in the treatment of obsessive-compulsive disorder: A preliminary single-blind, 12-week, controlled study [J].
Albert, U ;
Aguglia, E ;
Maina, G ;
Bogetto, F .
JOURNAL OF CLINICAL PSYCHIATRY, 2002, 63 (11) :1004-1009
[3]  
Barr LC, 1997, AM J PSYCHIAT, V154, P1293
[4]  
BENFIELD DP, 1980, POSTGRAD MED J, V56, P13
[5]  
Bystritsky A, 2004, J CLIN PSYCHIAT, V65, P565
[6]   A double blind comparison of venlafaxine and paroxetine in obsessive-compulsive disorder [J].
Denys, D ;
van der Wee, N ;
van Megen, HJGM ;
Westenberg, HGM .
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 2003, 23 (06) :568-575
[7]  
Denys D, 2004, J CLIN PSYCHIAT, V65, P1040
[8]  
Denys D, 2004, J CLIN PSYCHIAT, V65, P37
[9]  
Devarajan S, 2000, CAN J PSYCHIAT, V45, P489
[10]   Reboxetine plus citalopram for refractory depression not responding to venlafaxine: possible mechanisms [J].
Dursun, SM ;
Devarajan, S .
PSYCHOPHARMACOLOGY, 2001, 153 (04) :497-498