Studies on manufacturing of topical wound dressings based on nanosilver produced by aqueous molecular solution method

Nanosilver-based wound dressings were manufactured by immersing non-woven fabric material into a nanosilver solution at a concentration of 500 mg/L with an average particle size of 20-25 nm, which was produced by the aqueous molecular solution method using sodium borohydride as a reducing agent and chitosan as a stabiliser. The bactericidal activity of the nanosilver-based wound dressings has been assessed on three standard bacterial strains Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853 and Staphylococcus aureus ATCC 25923, as well as P. aeruginosa, S. aureus and Acinetobacter baumannii isolated from patients' burns. The results showed that these products are effective bactericides against both the standard strains and those isolated from patients' burns. The effect of the dressings on burn treatment has been investigated using laboratory rabbits. It was proved that for the burn healing, the produced nanosilver-coated wound dressings are as effective as the Chinese Anson's ones.