Extracts of Phellinus linteus grown on germinated brown rice suppress liver damage induced by carbon tetrachloride in rats

被引：59

作者：

Jeon, TI

Hwang, SG

Lim, BO

Park, DK ^{[1
]}

机构：

[1] Konkuk Univ, Dept Appl Biol & Chem, Seoul 143701, South Korea

[2] Hankyong Natl Univ, Dept Dairy Sci, Ansung 456749, South Korea

来源：

BIOTECHNOLOGY LETTERS | 2003年 / 25卷 / 24期

关键词：

antioxidant enzyme; carbon tetrachloride; cytochrome P450 2E1; lipid peroxidation; Phellinus linteus;

D O I：

10.1023/B:BILE.0000007071.28105.c1

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Extracts of Phellinus linteus (EPB), grown on germinated brown rice, protected rats from liver injury induced by carbon tetrachloride (CCl4). Peroxidation products in the liver were decreased to 10% by EPB. Catalase and superoxide dismutase activities were significantly decreased to 55% and 39% by CCl4 administration, but EPB blocked this effect, resulting in enzyme activities at control levels. Expression of cytochrome P450 2E1 (CYP2E1) protein was significantly decreased to 88% in CCl4-treated rats but remained at control levels when EPB was also administered. EPB did not affect the altered fatty acid composition induced by CCl4. The hepatoprotective effect of EPB may be mediated by EPB's prevention of CCl4-induced CYP2E1 degradation.

引用

页码：2093 / 2096

页数：4

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