T cells and adaptive immunity to Mycobacterium tuberculosis in humans

被引：314

作者：

Jasenosky, Luke D. ^{[1
]}

Scriba, Thomas J. ^{[2
,3
]}

Hanekom, Willem A. ^{[2
,3
,4
]}

Goldfeld, Anne E. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Boston Childrens Hosp, Program Cellular & Mol Med, Boston, MA USA

[2] Univ Cape Town, South African TB Vaccine Initiat, Inst Infect Dis & Mol Med, ZA-7925 Cape Town, South Africa

[3] Univ Cape Town, Sch Child & Adolescent Hlth, ZA-7925 Cape Town, South Africa

[4] Bill & Melinda Gates Fdn, Seattle, WA USA

来源：

IMMUNOLOGICAL REVIEWS | 2015年 / 264卷 / 01期

关键词：

TB; CD4(+); CD8(+); IL-10-producing immunosuppressive and Treg cells; Th1 and Th17 cells; HIV co-infection; CALMETTE-GUERIN VACCINATION; HIV-INFECTED INDIVIDUALS; SKIN-TEST RESPONSE; CD8(+) T; ACTIVE TUBERCULOSIS; PULMONARY TUBERCULOSIS; ANTIRETROVIRAL THERAPY; INTERFERON-GAMMA; IFN-GAMMA; POLYFUNCTIONAL CD4(+);

D O I：

10.1111/imr.12274

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The adaptive immune response mediated by T cells is critical for control of Mycobacterium tuberculosis (M.tuberculosis) infection in humans. However, the M.tuberculosis antigens and host T-cell responses that are required for an effective adaptive immune response to M.tuberculosis infection are yet to be defined. Here, we review recent findings on CD4(+) and CD8(+) T-cell responses to M.tuberculosis infection and examine the roles of distinct M.tuberculosis-specific T-cell subsets in control of de novo and latent M.tuberculosis infection, and in the evolution of T-cell immunity to M.tuberculosis in response to tuberculosis treatment. In addition, we discuss recent studies that elucidate aspects of M.tuberculosis-specific adaptive immunity during human immunodeficiency virus co-infection and summarize recent findings from vaccine trials that provide insight into effective adaptive immune responses to M.tuberculosis infection.

引用

页码：74 / 87

页数：14

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