T cells and adaptive immunity to Mycobacterium tuberculosis in humans

被引：314

作者：

Jasenosky, Luke D. ^{[1
]}

Scriba, Thomas J. ^{[2
,3
]}

Hanekom, Willem A. ^{[2
,3
,4
]}

Goldfeld, Anne E. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Boston Childrens Hosp, Program Cellular & Mol Med, Boston, MA USA

[2] Univ Cape Town, South African TB Vaccine Initiat, Inst Infect Dis & Mol Med, ZA-7925 Cape Town, South Africa

[3] Univ Cape Town, Sch Child & Adolescent Hlth, ZA-7925 Cape Town, South Africa

[4] Bill & Melinda Gates Fdn, Seattle, WA USA

来源：

IMMUNOLOGICAL REVIEWS | 2015年 / 264卷 / 01期

关键词：

TB; CD4(+); CD8(+); IL-10-producing immunosuppressive and Treg cells; Th1 and Th17 cells; HIV co-infection; CALMETTE-GUERIN VACCINATION; HIV-INFECTED INDIVIDUALS; SKIN-TEST RESPONSE; CD8(+) T; ACTIVE TUBERCULOSIS; PULMONARY TUBERCULOSIS; ANTIRETROVIRAL THERAPY; INTERFERON-GAMMA; IFN-GAMMA; POLYFUNCTIONAL CD4(+);

D O I：

10.1111/imr.12274

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The adaptive immune response mediated by T cells is critical for control of Mycobacterium tuberculosis (M.tuberculosis) infection in humans. However, the M.tuberculosis antigens and host T-cell responses that are required for an effective adaptive immune response to M.tuberculosis infection are yet to be defined. Here, we review recent findings on CD4(+) and CD8(+) T-cell responses to M.tuberculosis infection and examine the roles of distinct M.tuberculosis-specific T-cell subsets in control of de novo and latent M.tuberculosis infection, and in the evolution of T-cell immunity to M.tuberculosis in response to tuberculosis treatment. In addition, we discuss recent studies that elucidate aspects of M.tuberculosis-specific adaptive immunity during human immunodeficiency virus co-infection and summarize recent findings from vaccine trials that provide insight into effective adaptive immune responses to M.tuberculosis infection.

引用

页码：74 / 87

页数：14

共 210 条

[11] A Broad Profile of Co-Dominant Epitopes Shapes the Peripheral Mycobacterium tuberculosis Specific CD8+T-Cell Immune Response in South African Patients with Active Tuberculosis [J].

Axelsson-Robertson, Rebecca ;

Loxton, Andre G. ;

Walzl, Gerhard ;

Ehlers, Marthie M. ;

Kock, Marleen M. ;

Zumla, Alimuddin ;

Maeurer, Markus .

PLOS ONE, 2013, 8 (03)

[12] Th2 biased immune response in cases with active Mycobacterium tuberculosis infection and tuberculin anergy [J].

Balikó, Z ;

Szereday, L ;

Szekeres-Bartho, J .

FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, 1998, 22 (03) :199-204

[13] Phosphorylated STAT3 and PD-1 regulate IL-17 production and IL-23 receptor expression in Mycobacterium tuberculosis infection [J].

Bandaru, Anuradha ;

Devalraju, Kamakshi P. ;

Paidipally, Padmaja ;

Dhiman, Rohan ;

Venkatasubramanian, Sambasivan ;

Barnes, Peter F. ;

Vankayalapati, Ramakrishna ;

Valluri, Vijayalakshmi .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2014, 44 (07) :2013-2024

[14] The role of coinfections in HIV epidemic trajectory and positive prevention: a systematic review and meta-analysis [J].

Barnabas, Ruanne V. ;

Webb, Emily L. ;

Weiss, Helen A. ;

Wasserheit, Judith N. .

AIDS, 2011, 25 (13) :1559-1573

[15] CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity [J].

Belkaid, Y ;

Piccirillo, CA ;

Mendez, S ;

Shevach, EM ;

Sacks, DL .

NATURE, 2002, 420 (6915) :502-507

[16] An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis [J].

Berry, Matthew P. R. ;

Graham, Christine M. ;

McNab, Finlay W. ;

Xu, Zhaohui ;

Bloch, Susannah A. A. ;

Oni, Tolu ;

Wilkinson, Katalin A. ;

Banchereau, Romain ;

Skinner, Jason ;

Wilkinson, Robert J. ;

Quinn, Charles ;

Blankenship, Derek ;

Dhawan, Ranju ;

Cush, John J. ;

Mejias, Asuncion ;

Ramilo, Octavio ;

Kon, Onn M. ;

Pascual, Virginia ;

Banchereau, Jacques ;

Chaussabel, Damien ;

O'Garra, Anne .

NATURE, 2010, 466 (7309) :973-U98

[17] Earlier versus Later Start of Antiretroviral Therapy in HIV-Infected Adults with Tuberculosis [J].

Blanc, Francois-Xavier ;

Sok, Thim ;

Laureillard, Didier ;

Borand, Laurence ;

Rekacewicz, Claire ;

Nerrienet, Eric ;

Madec, Yoann ;

Marcy, Olivier ;

Chan, Sarin ;

Prak, Narom ;

Kim, Chindamony ;

Lak, Khemarin Kim ;

Hak, Chanroeurn ;

Dim, Bunnet ;

Sin, Chhun Im ;

Sun, Sath ;

Guillard, Bertrand ;

Sar, Borann ;

Vong, Sirenda ;

Fernandez, Marcelo ;

Fox, Lawrence ;

Delfraissy, Jean-Francois ;

Goldfeld, Anne E. .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (16) :1471-1481

[18] Transcriptional Blood Signatures Distinguish Pulmonary Tuberculosis, Pulmonary Sarcoidosis, Pneumonias and Lung Cancers [J].

Bloom, Chloe I. ;

Graham, Christine M. ;

Berry, Matthew P. R. ;

Rozakeas, Fotini ;

Redford, Paul S. ;

Wang, Yuanyuan ;

Xu, Zhaohui ;

Wilkinson, Katalin A. ;

Wilkinson, Robert J. ;

Kendrick, Yvonne ;

Devouassoux, Gilles ;

Ferry, Tristan ;

Miyara, Makoto ;

Bouvry, Diane ;

Dominique, Valeyre ;

Gorochov, Guy ;

Blankenship, Derek ;

Saadatian, Mitra ;

Vanhems, Phillip ;

Beynon, Huw ;

Vancheeswaran, Rama ;

Wickremasinghe, Melissa ;

Chaussabel, Damien ;

Banchereau, Jacques ;

Pascual, Virginia ;

Ho, Ling-pei ;

Lipman, Marc ;

O'Garra, Anne .

PLOS ONE, 2013, 8 (08)

[19] Expression of ectonucleotidase CD39 by Foxp3+ Treg cells:: hydrolysis of extracellular ATP and immune suppression [J].

Borsellino, Giovanna ;

Kleinewietfeld, Markus ;

Di Mitri, Diletta ;

Sternjak, Alexander ;

Diamantini, Adamo ;

Giometto, Raffaella ;

Hoepner, Sabine ;

Centonze, Diego ;

Bernardi, Giorgio ;

Dell'Acqua, Maria Luisa ;

Rossini, Paolo Maria ;

Battistini, Luca ;

Rotzschke, Olaf ;

Falk, Kirsten .

BLOOD, 2007, 110 (04) :1225-1232

[20] ASSOCIATION OF TUBERCULOSIS AND M-TUBERCULOSIS-SPECIFIC ANTIBODY-LEVELS WITH HLA [J].

BOTHAMLEY, GH ;

BECK, JS ;

SCHREUDER, GMT ;

DAMARO, J ;

DEVRIES, RRP ;

KARDJITO, T ;

IVANYI, J .

JOURNAL OF INFECTIOUS DISEASES, 1989, 159 (03) :549-555

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