Synthesis of (5,6&6,6)-oxa-oxa annulated sugars as glycosidase inhibitors from 2-formyl galactal using iodocyclization as a key step

被引：35

作者：

Rajasekaran, Parasuraman ^{[1
]}

Ande, Chennaiah ^{[1
]}

Vankar, Yashwant D. ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, Kanpur 208016, Uttar Pradesh, India

来源：

ARKIVOC | 2022年

关键词：

Iodocyclization; 2-formyl galactal; annulated sugars; glycosidase inhibitors; C-GLYCOSIDES; AMINO-ACID; GLYCALS; HYBRIDS; ENTRY;

D O I：

10.24820/ark.5550190.p011.809

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Oxa-oxa (5,6 & 6,6) annulated sugars were synthesized from 2-formyl galactal using iodocyclization as a key step. The glycosidase inhibitory activities of the synthesized molecules were tested against commercially available enzymes which showed that the sugar-furan molecules are potent and selective inhibitors. [GRAPHICS] .

引用

页码：5 / 23

页数：19

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